Synthesis and Antitumor Evaluation of Some Novel Pyrrolizine Derivatives
- Citation:
- Hanna, M. M., N. M. Abdelgawad, N. A. Ibrahim, and A. B. Mohammed, "Synthesis and Antitumor Evaluation of Some Novel Pyrrolizine Derivatives", Med Chem Res, vol. 21, pp. 2349–2362, 2011.
Abstract:
Pyrrolizine ring constitutes an important skeleton for many natural and synthetic compounds of diverse biological activities. Furthermore, it represents a key nucleus for the synthesis of many antitumor drugs Therefore, novel series of pyrrolizines, pyrimido[5,4-a]pyrrolizines and pyrido[3,2-a]pyrrolizineswere synthesized through different reactions. The chemical structures of all the synthesized pyrrolizine derivatives were determined by spectral and elemental analyses. Antitumor activity evaluation of all the prepared compounds was carried out using NR assay method against breast cancer cell line (MCF-7). The novel pyrrolizine scaffold 7 and all its prepared derivatives showed high antitumor activity comparable to that of doxorubicin.
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