Medical Sector

Citation:

Bassiouny, D., and O. Shaker, "Role of Interleukin-17 in the Pathogenesis of Vitiligo", Clinical and Experimental Dermatology, 2011.

Abstract:

Background: Skewing of the immune response towards T helper (Th)1 or Th17 and away from regulatory T cells (Tregs) and Th2 cells may be responsible for the development and progression of autoimmune disease. An autoimmune theory has been proposed in the pathogenesis of vitiligo. No previous reports have investigated alterations in IL-17 produced by Th17 cells in lesional skin in vitiligo. Aim: To investigate the role of IL-17 in the pathogenesis of vitiligo by assessing its levels in lesional skin and serum of patients with vitiligo compared with controls. Methods: In total, 30 patients with vitiligo and 20 controls matched for age and gender were enrolled in the study. Serum and tissue IL-17 levels were measured by ELISA and compared between both groups for correlations with age, gender, family, disease duration, activity of vitiligo and percentage of involved body surface area. Results: A significant difference between patients and healthy controls was found for both serum and tissue IL-17 levels (P < 0.001 for both). Significant positive correlations were found between

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