Interactive effects of cadmium and titanium dioxide nanoparticles on hepatic tissue in rats: Ameliorative role of coenzyme 10 via modulation of the NF-κB and TNFα pathway.
- Citation:
- Abd-Elhakim, Y. M., M. M. M. Hashem, K. Abo-EL-Sooud, M. R. Mousa, A. M. Soliman, S. M. Mouneir, S. H. Ismail, B. A. Hassan, and H. H. M. El-Nour, "Interactive effects of cadmium and titanium dioxide nanoparticles on hepatic tissue in rats: Ameliorative role of coenzyme 10 via modulation of the NF-κB and TNFα pathway.", Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, vol. 182, pp. 114191, 2023.
Abstract:
This study investigated the effect of oral dosing of titanium dioxide nanoparticles (TNPs) and cadmium (Cd) on rat liver and the potential protective role of coenzyme Q10 (CQ10) against TNPs and Cd-induced hepatic injury. Seventy male Sprague Dawley rats were divided into seven groups and orally given distilled water, corn oil, CQ10 (10 mg/kg b.wt), TNPs (50 mg/kg b.wt), Cd (5 mg/kg b.wt), TNPs + Cd, or TNPs + Cd+CQ10 by gastric gavage for 60 successive days. The results showed that individual or mutual exposure to TNPs and Cd significantly increased the serum levels of various hepatic enzymes and lipids, depleted the hepatic content of antioxidant enzymes, and increased malondialdehyde. Moreover, the hepatic titanium and Cd content were increased considerably in TNPs and/or Cd-exposed rats. Furthermore, marked histopathological perturbations with increased immunoexpression of tumor necrosis factor-alpha and nuclear factor kappa B were evident in TNPs and/or Cd-exposed rats. However, CQ10 significantly counteracted the damaging effect of combined exposure of TNPs and Cd on the liver. The study concluded that TNPs and Cd exposure harm hepatic function and its architecture, particularly at their mutual exposure, but CQ10 could be a candidate protective agent against TNPs and Cd hepatotoxic impacts.