Publications

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Submitted
El-Mahallawy, H. A., N. E. Abdelfattah, M. A. Wassef, and R. M. Abdel-Hamid, "Alarming Increase of Amole-Resistant Candida Causing Blood Stream Infections in Oncology Patients in Egypt", Curr Microbiol, vol. 80, issue 11, pp. 362-366, Submitted.
Abdel-Hamid, R. M., H. A. El-Mahallawy, N. E. Abdelfattah, and M. A. Wassef, "The impact of increasing non-albicans Candida trends on diagnostics in immunocompromised patients", Braz J Microbiol, vol. 54, issue 4, pp. 2879-2892, Submitted.
Abdel-Hamid, R. M., H. A. El-Mahallawy, N. E. Abdelfattah, and M. A. Wassef, "The impact of increasing non-albicans Candida trends on diagnostics in immunocompromised patients", Braz J Microbiol, vol. 54, issue 4, pp. 2879-2892, Submitted.
Abdel-Hamid, R. M., H. A. El-Mahallawy, N. E. Abdelfattah, and M. A. Wassef, "The impact of increasing non-albicans Candida trends on diagnostics in immunocompromised patients", Braz J Microbiol, vol. 54, issue 4, pp. 2879-2892, Submitted.
Abdel-Hamid, R. M., H. A. El-Mahallawy, N. E. Abdelfattah, and M. A. Wassef, "The impact of increasing non-albicans Candida trends on diagnostics in immunocompromised patients", Braz J Microbiol, vol. 54, issue 4, pp. 2879-2892, Submitted.
Mahmoud, F. M., R. A. Khedr, E. Ebeid, H. A. El-Mahallawy, and S. S. Hassan, "Impact of Rapid Molecular Diagnostic Technique on Time to Optimal Antimicrobial Therapy and Hospital Outcomes in Pediatric Cancer Patients with Sepsis", Asian Pac J Cancer Prev, vol. 24, issue 7, pp. 2465-2471, Submitted.
2022
El-Mahallawy, H. A., marwa elswify, A. A. Hak, and M. M. Zafer, "Increasing trends of colistin resistance in patients at high-risk of Carbapenem-resistant Enterobacteriaceae ", Ann Med, vol. 54, issue 1, pp. 1-9, 2022.
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2021
El-Mahallawy, H. A., R. M. El-Gendi, D. M. Ghaith, I. K. Behiry, and S. F. Helal, "Galactomannan and 1, 3-B-D-Glucan Assay in Broncholveolar Lavage Fluid for the Diagnosis of Invasive Pulmonary Aspergillosis in Malignant and Non-malignant Patients", Macedonian Journal of Medical Sciences, vol. 9, issue A, pp. 362-366, 2021.
El-Kholy, A., H. A. El-Mahallawy, N. Elsharnouby, M. abd elaziz, A. M. Helmy, and R. Kotb, "Landscape of Multidrug-Resistant Gram-Negative Infections in Egypt: Survey and Literature Review.", Infection and drug resistance, vol. 14, pp. 1905-1920, 2021. Abstract
application/pdf iconidr-298920-landscape-of-multidrug-resistant-gram-negative-infections-in.pdf

PURPOSE: This article is the first to review published reports on the prevalence of multidrug-resistant (MDR) gram-negative infections in Egypt and gain insights into antimicrobial resistance (AMR) surveillance and susceptibility testing capabilities of Egyptian medical centers.

MATERIALS AND METHODS: A literature review and online survey were conducted.

RESULTS: The online survey and literature review reported high prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (19-85.24% of , and 10-87% of ), carbapenem-resistant Enterobacteriaceae (35-100% of and 13.8-100% of ), carbapenem-resistant (10-100%), and carbapenem-resistant (15-70%) in Egypt. Risk factors for MDR Gram-negative infections were ventilated patients (67.4%), prolonged hospitalization (53.5%) and chronic disease (34.9%). Although antimicrobial surveillance capabilities were deemed at least moderate in most centers, lack of access to rapid AMR diagnostics, lack of use of local epidemiological data in treatment decision-making, lack of antimicrobial stewardship (AMS) programs, and lack of risk prediction tools were commonly reported by respondents.

CONCLUSION: This survey has highlighted the presence of knowledge gaps as well as limitations in the surveillance and monitoring capabilities of AMR in Egypt, with most laboratories lacking rapid diagnostics and molecular testing. Future efforts in Egypt should focus on tackling these issues via nationwide initiatives, including understanding the AMR trends in the country, capacity building of laboratories and their staff to correctly and timely identify AMR, and introducing newer antimicrobials for targeting emerging resistance mechanisms in Gram-negative species.

, "molecular characterization of carbapenemase-producing Klebsiella pneumoniae isolated from Egyptian pediatric cancer patients including a strain with a rare gene-combination of B-lactamases", Infection and Drug Resistance, vol. 14, pp. 335- 348, 2021.
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, "Severe COVID-19 and sepsis: Immune pathogenesis and laboratory markers", Microorganisms, vol. 9, issue 1, pp. 159- 171, 2021.
2020
Hamdy, R., H. El-Mahallawy, and E. Ebeid, "COVID-19 infection in febrile neutropenic pediatric hematology oncology patients", Pediatric Blood and Cancer, 2020.
, "The TACTIC experience: establishing an international, interdisciplinary network to tackle antimicrobial resistance", J Med Microbiol, vol. 69, issue 10, pp. 1213- 1220, 2020.
2019
L, A. - H., R. - M. A, N. M, and El-Mahallawy, "Identtifying barriers to implementation of antimicrobial resistance policies: a pilot study in a lower middle-income country through cross-disciplinary collaboration", ECCMID= European conference of clinical microbiology and infectious diseases, Amsterdam, Netherlands, 13 April, 2019.
El-Mahallawy, Z. M, R. M, and A. M, "The role of class I integron in the transmission of carbapenem resistance in oxa-48 producing Escherechia coli clinical isolates", ECCMID= European conference of clinical microbiology and infectious diseases, Amsterdam, Netherlands, 13 April, 2019.
DU, S. E. D., A. M, E. - M. H, and R. S, "Characterization of the type of response to different HCV antigens and quantification of viral load in newly diagnosed hepatocellular carcinoma patients", The Egyptian Journal of Hospital Medicine, vol. 76, issue 7, pp. 4669-4674, 2019.
M, Z., E. - M. H, A. A, and A. M, "Emergence of Colistin Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli Strains Isolated from Cancer Patients", Ann Clin Microbiol Antimicrob, vol. 18, issue 1, pp. 40- 48, 2019.
L, A. - H., Z. M, and E. - M. H, "Multiple sequence types responsible for health-care associated Acinetobacter baumanii dissemination in a single centre in Egypt", BMC Infect Dis, vol. 19, pp. 829- 834, 2019.
Y, M., K. R, A. N, and El-Mahallawy, "Overview and Outcome of Mucormycoss Among Children With Cancer: Report From the Children's Cancer Hospital Egypt", Mycoses, vol. 62, issue 11, pp. 984-989, 2019.
M, E. F., E. - M. H, and Attia AS, "Tracing the dissemination of the international clones of multidrug-resistant Acinetobacter baumanii among cancer patients in Egypt using the PCR-based open reading frame typing (POT) method", Journal of Global Antimicrobial Resistance, vol. 19, issue 1, pp. 210-215, 2019.