Publications

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2021
El-Kholy, A., H. A. El-Mahallawy, N. Elsharnouby, M. abd elaziz, A. M. Helmy, and R. Kotb, "Landscape of Multidrug-Resistant Gram-Negative Infections in Egypt: Survey and Literature Review.", Infection and drug resistance, vol. 14, pp. 1905-1920, 2021. Abstract

PURPOSE: This article is the first to review published reports on the prevalence of multidrug-resistant (MDR) gram-negative infections in Egypt and gain insights into antimicrobial resistance (AMR) surveillance and susceptibility testing capabilities of Egyptian medical centers.

MATERIALS AND METHODS: A literature review and online survey were conducted.

RESULTS: The online survey and literature review reported high prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (19-85.24% of , and 10-87% of ), carbapenem-resistant Enterobacteriaceae (35-100% of and 13.8-100% of ), carbapenem-resistant (10-100%), and carbapenem-resistant (15-70%) in Egypt. Risk factors for MDR Gram-negative infections were ventilated patients (67.4%), prolonged hospitalization (53.5%) and chronic disease (34.9%). Although antimicrobial surveillance capabilities were deemed at least moderate in most centers, lack of access to rapid AMR diagnostics, lack of use of local epidemiological data in treatment decision-making, lack of antimicrobial stewardship (AMS) programs, and lack of risk prediction tools were commonly reported by respondents.

CONCLUSION: This survey has highlighted the presence of knowledge gaps as well as limitations in the surveillance and monitoring capabilities of AMR in Egypt, with most laboratories lacking rapid diagnostics and molecular testing. Future efforts in Egypt should focus on tackling these issues via nationwide initiatives, including understanding the AMR trends in the country, capacity building of laboratories and their staff to correctly and timely identify AMR, and introducing newer antimicrobials for targeting emerging resistance mechanisms in Gram-negative species.

, "Severe COVID-19 and sepsis: Immune pathogenesis and laboratory markers", Microorganisms, vol. 9, issue 1, pp. 159- 171, 2021.
2020
Hamdy, R., H. El-Mahallawy, and E. Ebeid, "COVID-19 infection in febrile neutropenic pediatric hematology oncology patients", Pediatric Blood and Cancer, 2020.
2019
L, A. - H., R. - M. A, N. M, and El-Mahallawy, "Identtifying barriers to implementation of antimicrobial resistance policies: a pilot study in a lower middle-income country through cross-disciplinary collaboration", ECCMID= European conference of clinical microbiology and infectious diseases, Amsterdam, Netherlands, 13 April, 2019.
El-Mahallawy, Z. M, R. M, and A. M, "The role of class I integron in the transmission of carbapenem resistance in oxa-48 producing Escherechia coli clinical isolates", ECCMID= European conference of clinical microbiology and infectious diseases, Amsterdam, Netherlands, 13 April, 2019.
DU, S. E. D., A. M, E. - M. H, and R. S, "Characterization of the type of response to different HCV antigens and quantification of viral load in newly diagnosed hepatocellular carcinoma patients", The Egyptian Journal of Hospital Medicine, vol. 76, issue 7, pp. 4669-4674, 2019.
M, Z., E. - M. H, A. A, and A. M, "Emergence of Colistin Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli Strains Isolated from Cancer Patients", Ann Clin Microbiol Antimicrob, vol. 18, issue 1, pp. 40- 48, 2019.
Y, M., K. R, A. N, and El-Mahallawy, "Overview and Outcome of Mucormycoss Among Children With Cancer: Report From the Children's Cancer Hospital Egypt", Mycoses, vol. 62, issue 11, pp. 984-989, 2019.
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