Publications

Export 9713 results:
Sort by: Author Title Type [ Year  (Desc)]
2024
Veys, K., M. A. Elmonem, L. van den Heuvel, W. A. Gahl, and E. Levtchenko, "Plasma chitotriosidase enzyme activity as a novel therapeutic monitor for cysteamine treatment in nephropathic cystinosis: A retrospective validation study.", Molecular genetics and metabolism, vol. 142, issue 1, pp. 108454, 2024. Abstract

BACKGROUND: Cystine-depleting therapy in nephropathic cystinosis is currently monitored via the white blood cell cystine assay, although its application and usefulness are limited by practical and technical issues. Therefore, alternative biomarkers that are widely available, more economical and less technically demanding, while reliably reflecting long-term adherence to cysteamine treatment, are desirable. Recently, we proposed chitotriosidase enzyme activity as a potential novel biomarker for the therapeutic monitoring of cysteamine treatment in cystinosis. In this study, we aimed to validate our previous findings and to confirm the value of chitotriosidase in the management of cystinosis therapy.

MATERIALS & METHODS: A retrospective study was conducted on 12 patients treated at the National Institutes of Health Clinical Center and followed up for at least 2 years. Plasma chitotriosidase enzyme activity was correlated with corresponding clinical and biochemical data.

RESULTS: Plasma chitotriosidase enzyme activity significantly correlated with WBC cystine levels, cysteamine total daily dosage and a Composite compliance score. Moreover, plasma chitotriosidase was a significant independent predictor for WBC cystine levels, and cut-off values were established in both non-kidney transplanted and kidney transplanted cystinosis patients to distinguish patients with a good versus poor compliance with cysteamine treatment. Our observations are consistent with those of our previous study and validate our findings.

CONCLUSIONS: Chitotriosidase enzyme activity is a valid potential alternative biomarker for monitoring cysteamine treatment in nephropathic cystinosis patients.

SYNOPSIS: Chitotriosidase enzyme activity is a valid potential alternative biomarker for monitoring cysteamine treatment in nephropathic cystinosis patients.

N, E. - A., B. H, A. M. F, and R. Y, "Plasma exchange is the hope for critically ill children with life-threatening autoimmune hemolytic anemia", https://epag.springeropen.com/, vol. 72, 2024.
Abdelgalil, A. I., A. M. Yassin, M. S. Khattab, E. A. Abdelnaby, S. A. Marouf, H. A. Farghali, and I. A. Emam, "Platelet-rich plasma attenuates the UPEC-induced cystitis via inhibiting MMP-2, 9 activities and downregulation of NGF and VEGF in Canis Lupus Familiaris model", Scientific Reports, vol. 14, issue 1, pp. 13612, 2024.
Abdelgalil, A. I., A. M. Yassin, M. S. Khattab, E. A. Abdelnaby, S. A. Marouf, H. A. Farghali, and I. A. Emam, "Platelet‑rich plasma attenuates the UPEC‑induced cystitis via inhibiting MMP‑2,9 activities and downregulation of NGF and VEGF in Canis Lupus Familiaris model", Scientific Reports, vol. 14, issue 1, pp. 13612, 2024. platelet-rich_plasma_attenuates.pdf
Alsiary, W. A., M. M. Y. Madany, and H. AbdElgawad, "The pleiotropic role of Salinicoccus bacteria in enhancing ROS homeostasis and detoxification metabolism in soybean and oat to cope with pollution of triclosan", Plant Physiology and Biochemistry, vol. 207: Elsevier Masson, pp. 108327, 2024. Abstract
n/a
Maged, A., M. Mabrouk, H. N. T. El-Din, L. Osama, S. M. Badr-Eldin, and A. A. Mahmoud, "PLGA and PDMS-based in situ forming implants loaded with rosuvastatin and copper-selenium nanoparticles: a promising dual-effect formulation with augmented antimicrobial and cytotoxic activity in breast cancer cells", Frontiers in Pharmacology, vol. 15, pp. 1397639, 2024.
El-Shiekh, R. A., M. R. Meselhy, R. Elshimy, Marwa A Ibrahim, M. E. Ali, and E. I. Hassanen, "Plumieride as a novel anti-fungal and anti-inflammatory iridoid against superficial candidiasis in mice", BMC Complementary Medicine and Therapies, vol. 24, no. 1: BioMed Central London, pp. 224, 2024. Abstract
n/a
El-Saadony, M. T., T. Yang, A. M. Saad, S. S. Alkafaas, S. S. Elkafas, G. S. Eldeeb, D. M. Mohammed, H. M. Salem, S. A. Korma, and S. A. Loutfy, "Polyphenols: Chemistry, bioavailability, bioactivity, nutritional aspects and human health benefits: A review", International journal of biological macromolecules, vol. 277, issue Pt. 3: Elsevier BV, 2024. Abstract
n/a
Kesba, H., S. EL-GANAİNY, W. Elmenofy, Samy Sayed, A. Abdel-Rahman, and S. DİAB, "POMEGRANATE (Punica granatum L.) GROWTH AND BİOCHEMİCAL ALTERATİONS İN RESPONSE TO MELOİDOGYNE İNCOGNİTA İNFECTİON, MİNERALS, AND NANO-FERTİLİZERS", Bioscience Journal , vol. 40, issue e40028, 2024. articlee40028-id70373.pdf
Kesba, H., S. El-Ganainy, W. Elmenofy, Samy Sayed, A. Abdel-Rahman, and S. Diab, "Pomegranate (Punica granatum L.) growth and biochemical alterations in response to meloidogyne incognita infection, minerals, and nano-fertilizers", Bioscience Journal, vol. 40, pp. e40028-e40028, 2024. Abstract
n/a
Mohsen, S., M. M. Bakr, M. A. ElDegwy, D. M. N. Abouhussein, A. R. Fares, and A. N. ElMeshad, "Pomegranate extract-loaded surfactant-free zein nanoparticles as a promising green approach for hepatic cancer: optimization and in vitro cytotoxicity", Future Journal of Pharmaceutical Sciences, vol. 10, pp. 73, 2024.
Mohsen, S., M. M. Bakr, M. A. ElDegwy, Dalia MN Abouhussein, A. R. Fares, and A. N. ElMeshad, "Pomegranate extract-loaded surfactant-free zein nanoparticles as a promisinggreen approach for hepatic cancer: optimization and in vitro cytotoxicity", Future Journal of Pharmaceutical Sciences, vol. 10, issue 73, pp. 1-17, 2024.
Hegazy, M. T., A. Maher, T. Algarf, M. Abdul-Aziz, L. Quartuccio, N. Zoheir, S. De Vita, and G. Ragab, POS1240 A CASE-CONTROL STUDY ON HCV PATIENTS WITH SICCA MANIFESTATIONS BEFORE AND AFTER DIRECT-ACTING ANTIVIRALS AND COMPARISON WITH SJOGREN’S DISEASE; INFECTION VERSUS AUTOIMMUNITY, : BMJ Publishing Group Ltd, 2024. Abstract
n/a
Osman, W. ’aA., H. Taher, H. Darweesh, M. A. Samie, O. G.Shaker, M. A. Samie, D. A. L., and H. Ateyya, "The possible anti-inflammatory effect of extra virgin olive oil with colchicine in treatment of resistant cases of familial Mediterranean fever in a cohort of pediatric Egyptian patients", Future journal of pharmaceutical sciences, vol. 10, issue 17@, 2024.
Osman, W. ’aA., H. Taher, H. Darweesh, M. A. Samie, O. G.Shaker, M. A. Samie, D. A. L., and H. Ateyya, "The possible anti-inflammatory effect of extra virgin olive oil with colchicine in treatment of resistant cases of familial Mediterranean fever in a cohort of pediatric Egyptian patients", Future journal of pharmaceutical sciences, vol. 10, issue 17@, 2024.
Osman, W. ’aA., H. Taher, H. Darweesh, M. A. Samie, O. G.Shaker, M. A. Samie, and D. A. L., "The possible anti-inflammatory effect of extra virgin olive oil with colchicine in treatment of resistant cases of familial Mediterranean fever in a cohort of pediatric Egyptian patients", Future journal of pharmaceutical sciences, vol. 10, issue 17@, 2024.
Eladwy, R. A., M. Alsherbiny, D. Chang, M. F. Metwaly, C. G. Li, and D. J. Bhuyan, "The postbiotic sodium butyrate synergizes the antiproliferative effects of dexamethasone against the AGS gastric adenocarcinoma cells", Frontiers in Nutrition, vol. 11: Frontiers, pp. 1372982, 2024. Abstract
n/a
Mostafa, N. A., A. H. S. Hamdi, and M. F. Fol, "Potential anthelmintic effect of chitosan on Syphacia muris infecting Wistar rats: biochemical, immunological, and histopathological studies", Scientific Reports, vol. 14, issue 1, pp. 2825, 2024.
Kotb, E. A., R. A. El-Shiekh, M. Hassan, W. H. Abd-Elsalam, N. El Tanbouly, and A. S. El Senousy, "Potential anti-acne loaded nanogel formulations of Origanum majorana L. and Chrysanthemum morifolium Ramat. essential oils", Applied Biological Chemistry, vol. 67:9, 2024.