Medical Sector

The present work reports the synthesis of 20 novel fluorine-containing quinoline and pyrimido[4,5-b]quinoline derivatives bearing a sulfonamide moiety.

Objective: The aim of this study was to assess the ability of hearing aid (HA) experience to improve central auditory skills by making use of auditory plasticity. The aim would be achieved through studying the unaided auditory perception of a time compressed sentence test (TCST)

Background: EORTC study 08021/ILCP 01/03 evaluated the role of consolidation gefitinib, an oral tyrosine kinase inhibitor (TKI), administered in patients with advanced non-small cell lung cancer (NSCLC), not progressing following standard 1st-line chemotherapy.

Early effect of elective percutaneous coronary intervention (PCI) is important in clinical practice. Knowledge of different variables for suboptimal effects of PCI may help to refine indications of and to guide strategies aimed at improving outcome. Objectives. To detect the early effects of elective PCI on different clinical and echocardiographic variables in the studied group and in different patient subgroups. Methods. Twenty-four patients with established coronary artery disease who are candidates for elective PCI of one or more of coronary vessels were enrolled in the study after exclusion of pts with acute MI and any contraindication for coronary angiography.

Background: The purpose of this study was to determine the role of the combined use of uterine artery Doppler velocimetry (UADV) and maternal serum placental growth factor (PlGF), vascular endothelial growth factor receptor-1 soluble fms-like tyrosine kinase-1 also called soluble (sVEGFR-1), and nitric oxide (NO) products concentrations for the prediction of preeclampsia in high-risk women and to compare these parameters between patients with mild and severe preeclampsia.

Objective: To evaluate the influence of 2% and 5% chlorhexidine (CHX) pretreatment on bond durability of a self-etching adhesive to normal (ND) and caries-affected (AD) dentin after 2-years of aging in artificial saliva and under simulated intrapulpal pressure (IPP). Methods : One hundred twenty freshly extracted carious teeth were ground to expose

Background: Many studies discussed the use of hypertonic solutions (HTS) for treatment of septic shock; however, they do not refer to the possible prophylactic benefit of early use of such solutions (before development of severe sepsis or septic shock).

Purpose: To histopathologically evaluate the influence of lyophilized human amniotic membrane transplant on the development of postoperative adhesions and fibrosis after extraocular muscle surgery.

As people enter old age, they begin to experience associated changes in their physical, mental and social health. Elderly individuals often develop feelings of loneliness, sullenness, depression and loss of self confidence. Reminiscence is a commonly-used clinical intervention to assist the elderly in adapting to the aging process. Therefore, this study was conducted to evaluate the effect of reminiscence on self-esteem, and depression among elderly people. A pre-post quasi-experimental design was utilized in this study. A sample of convenience of 30 institutionalized older adults was recruited from Dar El-Hana Geriatric home. Socio-demographic/medical data sheet, Mini-Mental State Exam (MMSE) scale, Geriatric Depression Scale (GDS), and Self-esteem Scale, were used to achieve the purpose of this study. A reminiscence program session was held for 90 minutes for a total of 10 weeks (20 sessions), the program focus on particular stages of life using a semi-structured interview. Findings of this study indicated that, reminiscence intervention significantly raised self-esteem, and the reduction in depression levels did not reach statistical significance. To conclude reminiscence intervention is an effective alternative intervention which can help living-alone elderly adapt to the aging process. Further studies about reminiscence on a larger number of elderly from different geographical areas are recommended.

This study was performed to evaluate the influence of surface roughness and adhesive system on the repair strength of silorane-based resin composite. Twenty-four substrate discs from silorane-based Filtek P90 were made and stored for 24 h. Half of the discs were roughened against 320 grit SiC paper while the other half was polished against 4000 grit SiC paper. All discs were etched with phosphoric acid. Repair resin composite, Filtek P90 or Filtek Z250, was bonded to the treated surfaces using their corresponding adhesive; Silorane Adhesive (SA) or Adper Scotchbond Multipurpose (SBMP) ending up with four repair groups. The groups were as follows: G1: Smooth + SA + Filtek P90; G2: Roughened + SA + Filtek P90; G3: Smooth + SBMP + Filtek Z250; G4: Roughened + SBMP + Filtek Z250. Additional six unrepaired discs from each resin composite (G5 and G6) were prepared to test the cohesive strength. After 24 h, discs (n = 6/group) were serially sectioned to obtain sticks (n = 30/group) for microtensile bond strength (?TBS) testing. Scanning electron microscopic

IF: 0.718

Objective: To determine whether the ultrasound-guided aspiration of hydrosalpingeal fluid at the time of oocyte retrievalvcan improve the outcomes of in vitro fertilisation-embryo transfer (IVF-ET).

IF: 1.438

Objective: The aim of the present study was to compare the cardioprotective effects of different therapies including local, remote, pharmacological and oxidative preconditioning in ischaemia/reperfusion injury in rats. Methodology Rats were randomly assigned into the following groups: sham-operated and myocardial ischaemia/reperfusion (40 min/10 min). Other groups were subjected to different preconditioning treatments before the operation. Two groups received oral doses of pioglitazone (10 mg/kg/day) or nicorandil (3 mg/kg/day) for 5 days. Other two groups were subjected to local or remote preconditioning by three cycles of 5 min of occlusion of either left descending coronary artery or right femoral artery followed by 5 min of reperfusion. The last two groups received either ozone (0.6 mg/kg/day in the first week followed by 1 mg/kg/day in the second week) or oxygen vehicle by rectal insufflations. Heart rate, ventricular arrhythmias and descending aortic blood flow were continuously recorded during the whole operation. Results: The arrhythmia score in all groups except ozone was reduced significantly compared to ischaemia/reperfusion group. Ventricular premature beats and bigeminy were significantly lowered in local preconditioning and pioglitazone groups. Trigeminy, salvos and ventricular tachycardia were completely abolished in local preconditioning and pioglitazone groups. Torsade de pointe was completely abolished in all treated groups except remote preconditioning. Ventricular tachycardia duration was significantly reduced in all groups compared to ischaemia/reperfusion group. Finally, descending aortic blood flow was seriously reduced during the incidence of ventricular arrhythmias which was significant in ischaemia/reperfusion group. All different preconditioning therapies show a protective effect against blood flow reduction. This was markedly observed in local preconditioning and ozone groups. Conclusion: Different preconditioning therapies exert a protective effect by reducing serious ventricular arrhythmias during myocardial ischaemia/reperfusion. This was markedly reflected in part by their blood flow preservative effects. Keywords: Arrhythmias; Ischemia; Nicorandil; Pioglitazone; Preconditioning; Reperfusion.

IF: 2.608

Several studies suggest that renal ischemia reperfusion (RIR) can induce acute kidney injury (AKI). However, remote effects of RIR injury need further investigations. Renal injury associated with liver disease or neurological manifestations is a common clinical problem.

This study researches the efficacy and safety of pegylated interferon alpha-2a (pegIFNa-2a) in Egyptian children and adolescents diagnosed with hepatitis C virus. Thirty patients were enrolled to receive pegIFN once a week with ribavirin twice daily for 12 weeks; viral load and experienced adverse effects were then assessed. Of the 30 patients, 16 (53.33%) were cleared from the virus, showing early virologic response (EVR). Three patients (10%) showed a 2-log reduction by week 12, with an overall early response rate of 63.33%. Three patients who showed EVR after 4 weeks relapsed by week 12. Levels of serum alanine aminotransferase (ALT) normalized at week 12. Adverse events included fever, myalgia, headache, flu-like symptoms, fatigue, anemia, and leucopenia; 63.33% of the patients showed significant reduction in their body weight. Although the patients showed a reduction in average body mass index, this reduction was not significant. Hemoglobin values decreased within the first 2 weeks and then stabilized but not back to baseline. A significant reduction in the level of absolute neutrophil count (ANC) was observed by the 4th week and started to improve by the 12th week. Of the recruited patients, 29.4% were subjected to IFN dose reduction. None of the patients with neutropenia developed serious infection or sepsis. The authors concluded that pegIFN plus ribavirin therapy is promising when tested on Egyptian children.

Purpose: To evaluate the retinal and optic nerve functions of bevacizumab when injected intravitreal in human eyes using electrophysiological tests; Electroretinogram (ERG) and Visual Evoked Potentials (VEP).

Objective: To assess the level of B-cell activating factor belonging to the tumor necrosis factor family (BAFF) also known as B lymphocyte stimulator (BLyS) and A Proliferation-Inducing Ligand (APRIL) in the serum of Juvenile Idiopathic Arthritis (JIA) patients in order to evaluate their role in the pathogenesis and detect any relation to the clinical manifestations and disease activity in the different subtypes of the disease.

Embryo transfer (ET) is the final critical step in IVF treatment. Despite its apparent simplicity, ET remains the rate limiting step in the success of IVF owing to the high rate of implantation failure. It is still an enigma why transfer is the most inefficient step.

Adenoid hypertrophy (AH) is a common cause of airway obstruction in children and its recurrence after conventional curettage adenoidectomy is not rare.

Object: This study compares endoscopic third ventriculostomy (ETV) and ventriculoperitoneal shunt (VPS) in the treatment of pediatric patients with marked obstructive hydrocephalus due to midline posterior fossa tumors.

Object: This study compares endoscopic third ventriculostomy (ETV) and ventriculoperitoneal shunt (VPS) in the treatment of pediatric patients with marked obstructive hydrocephalus due to midline posterior fossa tumors.

Object: Suprasellar arachnoid cysts (SACs) are rare, comprising approximately 10% of all intracranial arachnoid cysts. Although neuroendoscopic management is emerging as a safe effective alternative to microsurgery, the type of endoscopic surgery whether ventriculocystostomy (VC) or ventriculocystocisternostomy (VCC) is still controversial. This study evaluates the role of endoscopy in the treatment of SACs in children. It compares VC and VCC, to see which procedure is superior among the long-term follow-up.

Genetic factors contribute to the pathogenesis of coronary artery disease (CAD). We studied 100 patients with CAD and 50 healthy individuals to assess the association of endothelial nitric oxide (eNOS) polymorphism (Glu298Asp) and angiotensinogen polymorphisms (M235T) and CAD in an Egyptian population. Serum nitric oxide (NO) and angiotensin I levels were also measured. The frequency of Glu298Asp and M235T polymorphisms were higher in the CAD group compared with controls. The mean level of NO was significantly lower (P < .05) while angiotensin I was significantly higher (P < .05) in patients CAD than in controls. The frequency of eNOS TT allele of M235T variant was significantly higher in patients with CAD