Publications

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2023
Seif El-Din, S. H., O. A. Hammam, S. M. Ezzat, S. Saleh, M. M. Safar, W. E. - H. Maadawy, and N. M. El-Lakkany, "Hydroxysafflor yellow A protects against thioacetamide-induced liver fibrosis in rats via suppressing proinflammatory/fibrogenic mediators and promoting hepatic stellate cell senescence and apoptosis", Asian Pacific Journal of Tropical Biomedicine, vol. 13, issue 8, pp. 348-358, 2023. Manuscript
Ibrahim, A. A., S. A. S. Mageed, M. M. Safar, M. F. El-Yamany, and M. A. Oraby, "MitoQ alleviates hippocampal damage after cerebral ischemia: The potential role of SIRT6 in regulating mitochondrial dysfunction and neuroinflammation", Life Sciences, vol. 328, pp. 121895, 2023. mitoq_mamdouh_life_sciences.pdf
2022
Zaki, O. S., N. N. Nassar, D. M. Abdallah, M. M. Safar, and R. A. Mohammed, "Cilostazol Alleviates NLRP3 Inflammasome-Induced Allodynia/Hyperalgesia in Murine Cerebral Cortex Following Transient Ischemia: Focus on TRPA1/Glutamate and Akt/Dopamine/BDNF/Nrf2 Trajectories", Molecular Neurobiology , vol. 59, issue 12, pp. 7194-7211, 2022. allodynia.pdf
Lotfy, D. M., M. M. Safar, S. H. M. Hassan, and S. A. Kenawy, "Modulation of PTZ-induced convulsions in rats using topiramate alone or combined with low dose gamma irradiation: involving AKT/m-TOR pathway ", Toxicol Mech Methods, vol. 32, issue 1, pp. 18-26, 2022. topiramate_radiation_dina.pdf
Mohamed, A. F., H. M. Sayed, H. F. Zaki, and M. M. Safar, "Modulation of TLR4/NF-κB, Nrf2/HO-1 and PI3K/Akt signaling by cilostazol mitigates lipopolysaccharide-induced septic acute kidney injury ", Bulletin of Faculty of Pharmacy Cairo University:, vol. 60, issue 2, pp. 1-11, 2022. fathy_bulletin_of_faculty_of_pharmacy.pdf
Mohamed, A. F., H. M. Sayed, H. F. Zaki, and M. M. Safar, "Modulation of TLR4/NF-κB, Nrf2/HO-1 and PI3K/Akt signaling by cilostazol mitigates lipopolysaccharide-induced septic acute kidney injury ", Bulletin of Faculty of Pharmacy Cairo University:, vol. 60, issue 2, pp. 1-11, 2022. fathy_bulletin_of_faculty_of_pharmacy.pdf
Ammar, R. A., A. F. Mohamed, M. M. Kamal, M. M. Safar, and N. F. Abdelkader, "Neuroprotective effect of liraglutide in an experimental mouse model of multiple sclerosis: role of AMPK/SIRT1 signaling and NLRP3 infammasome ", Infammopharmacology, vol. 30, issue 3, pp. 919–934, 2022. reham_liraglutide.pdf
Ammar, R. A., A. F. Mohamed, M. M. Kamal, M. M. Safar, and N. F. Abdelkader, "Neuroprotective effect of liraglutide in an experimental mouse model of multiple sclerosis: role of AMPK/SIRT1 signaling and NLRP3 infammasome ", Infammopharmacology, vol. 30, issue 3, pp. 919–934, 2022. reham_liraglutide.pdf
Khalifa, M., R. M. Abdelsalam, M. M. Safar, and H. F. Zaki, "Phosphodiesterase (PDE) III inhibitor, Cilostazol, improved memory impairment in aluminum chloride-treated rats: modulation of cAMP/CREB pathway ", Inflammopharmacology, vol. 30, issue 6, pp. 2477-2488, 2022. cilostazol_mona_aluminium.pdf
Mahmoud, M. A., M. M. Safar, A. M. Agha, M. M. Khattab, and D. O. Saleh, "Telmisartan: An Angiotensin Receptor Blocker Regulates Osteoclastogenesis via Inhibition of the ERK Triggering in Osteoporotic Male Rats ", Fundam. Clin. Pharmacol, vol. 36, issue 5, pp. 869–878, 2022.
application/pdf icontelmisartan_m._a._aziz.pdf
2021
Ashoub, A. H., D. H. Abdel-Naby, M. M. Safar, M. A. El-Ghazaly, and S. A. Kenawy, "Ameliorative effect of fractionated low-dose gamma radiation in combination with ellagic acid on nicotine-induced hormonal changes and testicular toxicity in rats ", Environ Sci Pollut Res Int , vol. 28, issue 18, pp. 23287-23300, 2021. aliaa_nicotine.pdf
Arab, H. H., M. M. Safar, and N. N. Shahin, "argeting ROS-Dependent AKT/GSK-3β/NF-κB and DJ-1/Nrf2 Pathways by Dapagliflozin Attenuates Neuronal Injury and Motor Dysfunction in Rotenone-Induced Parkinson's Disease Rat Model", ACS Chem. Neurosci. , vol. 12, issue 4, pp. 689-703, 2021. dapagliflozin_and_parkinson's.pdf
Mahmoud, M. A. A., D. O. Saleh, M. M. Safar, A. M. Agha, and M. M. Khattab, "Chloroquine ameliorates bone loss induced by D-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect ", Toxicology Reports , vol. 8, pp. 366–375, 2021.
Aglan, H. S., M. M. Safar, A. A. - M. Ain-Shoka, A. M. Kandil, S. Gebremedhn, D. Salilew-Wondim, K. Schellander, and D. Tesfaye, "Developmental toxicity of lead in rats after gestational exposure and the protective role of taurine", J Biochem Mol Toxicol, vol. 35, issue 8, pp. e22816, 2021. hoda_lead.pdf
Safar, M. M., N. F. Abdelkader, E. Ramadan, M. A. Kortam, and A. F. Mohamed, "Novel mechanistic insights towards the repositioning of alogliptin in Parkinson's disease", Life Sciences, vol. 287, pp. 120132, 2021. Alogliptin.pdf
El-Maadawy, W. H., S. S. H. el-Din, S. M. Ezzat, O. A. Hammam, M. M. Safar, S. Saleh, and N. M. El-Lakkany, "Rutin Ameliorates Hepatic Fibrosis via Targeting Hepatic Stellate Cells’ Activation, Proliferation and Apoptosis ", Journal of Herbs, Spices & Medicinal Plants , vol. 27, issue 3, pp. 322–341, 2021. rutin_walaa_elmadawy.pdf
2020
Gowifel, A. M. H., M. G. Khalil, S. A. Nada, Sanaa A. Kenawy, K. A. Ahmed, M. M. Salama, and M. M. Safar, "Combination of pomegranate extract and curcumin ameliorates thioacetamide-induced liver fibrosis in rats: Impact on TGF-β/Smad3 and NF-κB signaling pathways", Toxicology Mechanisms and Methods, vol. 30, issue 8, pp. 620-633, 2020.
Hessin, A. F., R. R. Hegazy, M. M. Safar, N. Z. Yassin, and S. A. - B. Kenawy, "Construction and Assessment of a Novel Vaccine Targeting Hepatocellular Carcinoma", Egyptian Journal of Chemistry, vol. 63, issue 3, pp. 867-884, 2020. vaccine.pdf
Mohamed, M. A. E., R. F. Abdel-Rahman, S. S. Mahmoud, M. M. Khattab, and M. M. Safar, "Metformin and trimetazidine ameliorate diabetes-induced cognitive impediment in status epileptic rats", Epilepsy & Behavior, vol. 104, pp. 106893, 2020. Trimetazide.pdf
Nasr, N. A. E. - M. E., D. O. Saleh, S. S. Mahmoud, S. M. Nofal, R. M. Abdelsalam, M. M. Safar, and H. S. El-Abhar, "Olmesartan attenuates type 2 diabetes-associated liver injury: Cross-talk of AGE/RAGE/JNK, STAT3/SCOS3 and RAS signaling pathways", European Journal of Pharmacology, vol. 874, pp. 173010, 2020. Olmesartan.pdf
Safar, M. M., N. N. Shahin, A. F. Mohamed, and N. F. Abdelkader, "Suppression of BACE1 and amyloidogenic/RAGE axis by sitagliptin ameliorates PTZ kindling-induced cognitive deficits in rats", Chemico-Biological Interactions, vol. 328, pp. 109144, 2020. Sitagliptin.pdf
Khalifa, M., M. M. Safar, R. M. Abdelsalam2, and H. F. Zaki, "Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats", Neurotoxicity Research, vol. 37, issue 2, pp. 275-285, 2020. Telmisartan.pdf
2019
Oraby, M. A., M. F. El-Yamany, M. M. Safar, N. A. G. L. A. A. ASSAF, and H. A. Ghoneim, "Amelioration of Early Markers of Diabetic Nephropathy by Linagliptin in Fructose-Streptozotocin-Induced Type 2 Diabetic Rats ", Nephron, vol. 141, issue 4, pp. 273-286. , 2019. linagliptin_mamdouh.pdf
El-Lakkany, N. M., W. H. El-Maadawy, S. S. H. el-Din, S. Saleh, M. M.Safar, S. M. Ezzat, S. H. Mohamed, S. S. Botros, Z. Demerdash, and O. A. Hammam, Antifibrotic effects of gallic acid on hepatic stellate cells: In vitro and in vivo mechanistic study, , 2019. gallic_acid_walaa.pdf
Oraby, M. A., M. F. El-Yamany, M. M. Safar, N. A. G. L. A. A. ASSAF, and H. A. Ghoneim, "Dapagliflozin Attenuates Early Markers of Diabetic Nephropathy in Fructose-Streptozotocin-Induced Diabetes in Rats ", Biomedicine & Pharmacotherapy, vol. 109, pp. 910–920. , 2019.
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