Novel 5,6,7,8-tetrahydrobenzo[b]pyran Derivatives: Synthesis and Anticancer Activity
Many new cyclized pyran systems with a potential anti-cancer activity were designed and prepared. Pyran systems
showed high reactivity to various chemical reagents. 24 products of the prepared compounds were chosen and tested in
(mM) as respectable anticancer factors. The findings revealed that compounds 3b, 6b, and 8 were the widely effective
compounds against the three cancer cell lines including A-549 (lung carcinoma), HC-29 (colorectal adenocarcinoma),
and MKN-45 (gastric cancer) compared to the standard reference control foretinib.