Citation:

Nada, H. R., and L. A. Rashed, "Basic fibroblast growth factor & vitiligo", Journal of the Egyptian Women’s Dermatologic Society, vol. 9, issue 1, 2012.

Abstract:

Background: Previous studies have documented the role of Basic fibroblast growth factor (bFGF) in melanocyte growth, proliferation, and migration.Objective: This study assessed the level of bFGF in untreated vitiligo patients in both involved and noninvolved sites and compared them with normal controls.
Methods: Fifteen cases of vitiligo were enrolled in this study. Skin biopsy specimens were obtained from vitiligo lesions and from normal skin 2 cm away from the vitiligo lesions. Ten healthy controls were enrolled for comparison. Skin biopsies were subjected to bFGF quantitative assessment by enzyme-linked immune sorbent assay technique.
Results: Lower levels of bFGF were found in vitiligo lesions than in noninvolved sites. Normal controls have a higher level of bFGF compared with the involved and the noninvolved skin of vitiligo patients.
Conclusion: Basic FGF deficiency could be one of the etiological factors in the pathogenesis of vitiligo.

Notes:

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