Publications

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2024
Odeh, D. M., H. A. Allam, F. Baselious, W. R. Mahmoud, M. M. Odeh, H. S. Ibrahim, H. A. Abdel‐Aziz, and E. R. Mohammed, "Design, synthesis, and biological evaluation of dinaciclib and CAN508 hybrids as CDK inhibitors", Drug Development Research, vol. 85, issue 3, pp. e22193, 2024. paper_25.pdf
Moustafa, E. A., H. A. Allam, M. A. Fouad, E. A. M. Kerdawy, N. N. E. El-Sayed, C. Wagner, H. A. Abdel-Aziz, and M. A. Ezzat, "Discovery of novel quinolin-2-one derivatives as potential GSK-3β inhibitors for treatment of Alzheimer’s disease: Pharmacophore-based design, preliminary SAR, in vitro and in vivo biological evaluation", Bioorganic Chemistry , vol. 146, pp. 107324, 2024. paper24.pdf
Moustafa, E. A., H. A. Allam, M. A. Fouad, E. A. M. Kerdawy, N. N. E. El-Sayed, C. Wagner, H. A. Abdel-Aziz, and M. A. Ezzat, "Discovery of novel quinolin-2-one derivatives as potential GSK-3β inhibitors for treatment of Alzheimer’s disease: Pharmacophore-based design, preliminary SAR, in vitro and in vivo biological evaluation", Bioorganic Chemistry , vol. 146, pp. 107324, 2024. paper24.pdf
Moustafa, E. A., H. A. Allam, M. A. Fouad, E. A. M. Kerdawy, N. N. E. El-Sayed, C. Wagner, H. A. Abdel-Aziz, and M. A. Ezzat, "Discovery of novel quinolin-2-one derivatives as potential GSK-3β inhibitors for treatment of Alzheimer’s disease: Pharmacophore-based design, preliminary SAR, in vitro and in vivo biological evaluation", Bioorganic Chemistry , vol. 146, pp. 107324, 2024. paper24.pdf
Moustafa, E. A., H. A. Allam, M. A. Fouad, E. A. M. Kerdawy, N. N. E. El-Sayed, C. Wagner, H. A. Abdel-Aziz, and M. A. Ezzat, "Discovery of novel quinolin-2-one derivatives as potential GSK-3β inhibitors for treatment of Alzheimer’s disease: Pharmacophore-based design, preliminary SAR, in vitro and in vivo biological evaluation", Bioorganic Chemistry , vol. 146, pp. 107324, 2024. paper24.pdf
Moustafa, E. A., H. A. Allam, M. A. Fouad, E. A. M. Kerdawy, N. N. E. El-Sayed, C. Wagner, H. A. Abdel-Aziz, and M. A. Ezzat, "Discovery of novel quinolin-2-one derivatives as potential GSK-3β inhibitors for treatment of Alzheimer’s disease: Pharmacophore-based design, preliminary SAR, in vitro and in vivo biological evaluation", Bioorganic Chemistry , vol. 146, pp. 107324, 2024. paper24.pdf
Allam, H. A., D. M. Odeh, E. R. Mohammed, M. M. Odeh, W. R. Mahmoud, and H. A. Abdel-Aziz, "One-pot three-component synthesis, in vitro anticancer activity and p53-MDM2 protein-protein interaction inhibition of novel spiro-oxindoline-based pyrazolo[3,4-b]pyridines", Egyptian Journal of Chemistry , vol. 67, issue 3, pp. 495- 513, 2024. paper_22_.pdf
Mogheith, S., H. A. Allam, M. A. Ezzat, and S. Mohamady, "Overview on synthetic strategies and bioactivities of pyrazolopyridines", Egyptian Journal of Chemistry , vol. 67, issue 12, pp. 513 – 535 , 2024. paper_26.pdf
Moussa, A. M., H. A. Allam, M. K. El-Ashrey, M. A. Fouad, and A. A. Al-Karmalawy, "Rationale design and synthesis of new roflumilast analogues as preferential selective and potent PDE-4B inhibitors", Bioorganic Chemistry , vol. 153, pp. 107911, 2024. paper_27.pdf
Fahim, S. H., M. A. Alqadhi, H. A. Allam, F. A. Ragab, and T. A. A. Yahya, "Synthesis of some pyrazolo[1,5-a]pyrimidine derivatives bearing carbonitrile, amidoxime, carboxamide and oxadiazole substituents using commercially available reagents", Egyptian Journal of Chemistry , vol. 67, issue 3, pp. 475- 482, 2024.
2023
Metwally, H. M., H. A. Allam, F. Baselious, A. Bonardi, E. M. Seif, S. A. Moussa, E. Abdel-Latif, C. T. Supuran, and H. S. Ibrahim, "Arylidine extensions of 3-methyl-5-oxo-4,5-dihydro-1H-pyrazolbenzenesulfonamide derivatives: Synthesis, computational simulations and biological evaluation as tumor-associated carbonic anhydrase inhibitors", Bioorganic Chemistry , vol. 135, pp. 106492, 2023. paper_16.pdf
Al-Qadhi, M. A., H. A. Allam, S. H. Fahim, T. A. A. Yahya, and F. A. F. Ragab, "Design and synthesis of certain 7-Aryl-2-Methyl-3-Substituted Pyrazolo {1,5-a}Pyrimidines as multikinase inhibitors", European journal of medicinal chemistry, vol. 262, pp. 115918, 2023. paper_20.pdf
Al-Qadhi, M. A., H. A. Allam, S. H. Fahim, T. A. A. Yahya, and F. A. F. Ragab, "Design and synthesis of certain 7-Aryl-2-Methyl-3-Substituted Pyrazolo {1,5-a}Pyrimidines as multikinase inhibitors", European journal of medicinal chemistry, vol. 262, pp. 115918, 2023. paper_20.pdf
Oudah, K. H., W. R. Mahmoud, F. M. Awadallah, A. T. Taher, S. E. - S. Abbas, H. A. Allam, D. Vullo, and C. T. Supuran, "Design and synthesis of some new benzoylthioureido benzene sulfonamide derivatives and their analogues as carbonic anhydrase inhibitors", Journal of Enzyme Inhibition and Medicinal Chemistry , vol. 38, issue 1, pp. 12-23, 2023. paper_15.pdf
Ezzat, M. A. F., S. M. Abdel Hamid, M. A. Fouad, H. A. Abdel‐Aziz, and H. A. Allam, "Design, synthesis, in vitro, and in vivo evaluation of novel phthalazinone‐based derivatives as promising acetylcholinesterase inhibitors for treatment of Alzheimer's disease", Drug Development Research, pp. 1-16, 2023. paper_18.pdf
Allam, H. A., M. E. Albakry, W. R. Mahmoud, A. Bonardi, S. A. Moussa, S. Mohamady, H. A. - A. Aziz, C. T. Supuran, and H. S. Ibrahim, "Effect of hydrophobic extension of aryl enaminones and pyrazole-linked compounds combined with sulphonamide, sulfaguanidine, or carboxylic acid functionalities on carbonic anhydrase inhibitory potency and selectivity", Journal of Enzyme Inhibition and Medicinal Chemistry , vol. 38, issue 1, pp. 2201403, 2023. paper_17.pdf
Allam, H. A., M. E. Albakry, W. R. Mahmoud, A. Bonardi, S. A. Moussa, S. Mohamady, H. A. - A. Aziz, C. T. Supuran, and H. S. Ibrahim, "Effect of hydrophobic extension of aryl enaminones and pyrazole-linked compounds combined with sulphonamide, sulfaguanidine, or carboxylic acid functionalities on carbonic anhydrase inhibitory potency and selectivity", Journal of Enzyme Inhibition and Medicinal Chemistry , vol. 38, issue 1, pp. 2201403, 2023. paper_17.pdf
Rahman, A. D. E., M. A. Fouad, E. R. Mohammed, H. H. El-Zoheiry, and H. A. Allam, "Novel VEGFR-2 inhibitors as antiangiogenic and apoptotic agents via paracrine and autocrine cascades: Design, synthesis, and biological evaluation", Bioorganic Chemistry , vol. 139, pp. 106678, 2023. paper_19.pdf
2022
Farouk, A. K. B. A. W., H. A. Allam, E. Rashwan, R. F. George, and S. E. - S. Abbas, "Design and synthesis of some new 6-bromo-2-(pyridin-3-yl)-4-substituted quinazolines as multi tyrosine kinase inhibitors", Bioorganic Chemistry , vol. 128, pp. 106099, 2022. paper_13.pdf
Najm, M. A. A., W. R. Mahmoud, A. T. Taher, S. E. - S. Abbas, F. M. Awadallah, H. A. Allam, D. Vullo, and C. T. Supuran, "Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes", Journal of Enzyme Inhibition and Medicinal Chemistry , vol. 37, issue 1, pp. 2702-2709, 2022. paper_14.pdf
Ouf, A. M. A., H. A. Allam, M. Kamel, F. A. Ragab, and S. A. Abdel-Aziz, "Design, synthesis, cytotoxic and enzyme inhibitory activities of 1,3,4-oxadiazole and 1,3,4-thiadiazine hybrids against non-small cell lung cancer ", Results in Chemistry , vol. 4, pp. 100373, 2022.
M.Elimam, D., W. M. Eldehna, R. Salem, A. Bonardi, A. Nocentini, S. T.Al-Rashood, M. M. Elaasser, P. Gratteri, C. T.Supuran, and H.A.Allam, "Natural Inspired Ligustrazine-based SLC-0111 Analogues as Novel Carbonic Anhydrase Inhibitors", european journal of medicinal chemistry, vol. 228, pp. 114008, 2022.
2021
Ewida, M. A., H. A. Ewida, M. S. Ahmed, H. A. Allam, R. I. Elbagary, R. F. George, H. H. Georgey, and H. I. El-Subbagh, "3-Methyl-imidazo[2,1-b]thiazole derivatives as a new class of antifolates: Synthesis, in vitro/in vivo bio-evaluation and molecular modeling simulations", Bioorganic Chemistry , vol. 115, pp. 105205, 2021.
Amin, K. M., A. D. E. Rahman, H. A. Allam, and H. H. El-Zoheiry, "Design and synthesis of novel coumarin derivatives as potential acetylcholinesterase inhibitors for Alzheimer's disease’", Bioorganic Chemistry , vol. 110, pp. 104792, 2021.
Eissa, A. A. M., K. F. M. Aljamal, H. S. Ibrahim, and H. A. Allam, "Design and synthesis of novel pyridopyrimidine derivatives with anchoring non-coplanar aromatic extensions of EGFR inhibitory activity", Bioorganic Chemistry , vol. 115, pp. 105318, 2021.
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