Hanan Merey

Citation:

Rizk, M. S., H. A. Merey, S. M. Tawakkol, and M. N. Sweilam, "New potentiometric determination of clindamycin hydrochloride in pharmaceuticals", Research & Reviews in electrochemistry, vol. 4, issue (5), pp. 161-167, 2013.

Abstract:

A potentiometricmembrane sensor responsive with satisfactory selectivity
to clindamycin hydrochloride was prepared for simple and fast
determination of this drug in pure form and pharmaceutical dosage forms
without prior extraction process or separation from different dosage form
excipients. The sensor was based on the formation of an ion association
complex between clindamycin hydrochloride as a cationic drug and sodium
phosphotungestate as anionic electroactive material. The produced ion
association complex was incorporated in plasticized polyvinyl chloride
membrane. The performance characteristics of this sensors were evaluated
according to IUPAC recommendations-reveal fast, stable and near
Nernestian response for 3.16 × 10-4 - 1 × 10-1 M for clindamycin
hydrochloride. Statistical comparison between the results obtained by
applying the proposed potentiometric method for the determination of the
clindamycin hydrochloride and those obtained by applying the official
method was done and no significant difference was found at p = 0.05.
Validation of themethod according to ICH guidelines shows the suitability
of the sensor for quality control analysis of the cited drugs in
pharmaceutical formulations. The proposed sensors can also be used as a
detector for HPLCmethod.