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Today, the recombinant proteins become a major foundation of different industrial sectors. Products ofthese industries enhance the fields of medicine, pharmacology, agriculture, nutrition, petrochemicals,paper, textiles and many others. Since the mid 1980s, recombinant DNA technology has enabled thedevelopment of a wide diversity of vectors for expression of the desired recombinant protein innumerous prokaryotic and eukaryotic organisms. Baculovirus expression vector system is consideredone of the most successful and widely acceptable means for the production of recombinant proteins inextremely large quantities.

Today, the recombinant proteins become a major foundation of different industrial sectors. Products of these industries enhance the fields of medicine, pharmacology, agriculture, nutrition, petrochemicals, paper, textiles and many others. Since the mid 1980s, recombinant DNA technology has enabled the development of a wide diversity of vectors for expression of the desired recombinant protein in numerous prokaryotic and eukaryotic organisms. Baculovirus expression vector system is considered one of the most successful and widely acceptable means for production of recombinant proteins in extremely large quantities. Proper posttranslational modifications of the expressed proteins in insect cells, the usual host of baculoviruses, get them soluble, correctly folded and biologically active products. Along with the convenient biological safety, the easy scale up production of recombinant proteins into industrial levels brings this system the first choice in most cases. In the current review, different aspects of the baculovirus biology, structure and morphology are briefly covered to establish the basic concepts important for understanding the mechanisms involved in utilization of baculoviruses as expression vectors. Few outlines on the baculovirus expression system are discussed in terms of potentials, limitations, strategies and perspectives.

This article examines the use of digital media in the 2011 Egyptian revolution (25 January–11 February), termed by many analysts and commentators a “Facebook revolution”, “Twitter revolution”, “digital revolution” or “electronic revolution”. Such appellations highlight the role of the youth who organized and mobilized for the revolution and the essential role played by digital media. Disengaging from the controversial debate over whether Egypt’s revolution was instigated by social media or simply used them for its purposes, the article demonstrates the uncontestable role that social networks, text messages, and satellite news channels played as a tool of control and manipulation, on the one hand, and a mode of resistance, on the other. Delineating some key reasons why the Egyptian revolution came to be associated with digital media, the article shows the government’s reaction to the threat posed by such media through analysis of a key moment on the night of 27 and 28 January 2011, when the Egyptian government decided to cut off all Internet and smart phone connections. Through a detailed chronology of the development of events during that period of blockage, the article analyzes the government’s decision along two axes: manipulation through blockage and manipulation through propaganda and brainwashing. It concludes by showing how the government’s attempts to sabotage the revolution came in the end to be used subversively by the protestors as means of resistance. It injected the revolution with more momentum, and in fact inadvertently led to its success.

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A series of novel benzoxepin-derived compounds were synthesized and evaluated for their sedative-hypnotic effect using Phenobarbital induced sleep test in mice. Compound 6 in which the Phenobarbital moiety was incorporated into the benzoxepin nucleus was the most active one. Molecular modeling, including fitting to a 3D-pharmacophore model using Discovery Studio 2.1 programs into optimized benzodiazepine receptor (hypothesis) showed high fit values.

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