ALL schistosomicidal drugs eventually cause a change of location or ‘shift’ of the worms from the mesenteric veins, where they are normally found in infected animals, into the liver. There the parasites ultimately die and are ensheathed and phagocytosed by the protective mechanisms of the host. These worm migrations may be very rapid in onset and short in duration, as occurs with antimonials1; or they may be slow in onset and permanent in duration, as occurs with diphenoxyalkanes2. Various other schistosomicidal drugs produce ‘hepatic shifts’ with intermediate characteristics. The cause of the worm migrations differs with the different drugs, but essentially it results in paralysis of the worms which are thereafter swept back by the blood stream into the liver. Where the course of treatment is inadequate, the parasites regain their muscle control and return to the mesenteric veins.

The structure, distribution and dimensions of skin strata and sweat glands have been investigated in Egyptian buffaloes and cattle. Samples from sixteen body regions were taken from three adult bulls of both species. Identical studies were also made on one buffalo calf and two buffalo embryos. Serial vertical and horizontal sections were cut from each body region using the ‘terpineol paraffin wax’ method. The following results were obtained.