Ramadan, A.,
"Pharmacokinetics of tilmicosin in serum and milk of goats.",
Research in veterinary science, vol. 62, issue 1, pp. 48-50, 1997 Jan-Feb.
AbstractTilmicosin was administered to goats intravenously and subcutaneously to determine its concentration in blood and milk and its kinetic behaviour. After a slow intravenous injection, the serum concentration-time curve indicated a two compartment open model with a mean (SEM) elimination half-life (t1/2 beta S) of 4.36 (0.04) hours. After a subcutaneous injection the drug was eliminated more slowly from serum and milk, with t1/2 beta S of 29.3 and 41.4 hours, respectively. The apparent volume of distribution of tilmicosin was more than 1 litre kg-1. The peak serum tilmicosin concentration was 1.56 micrograms ml-1 6.39 hours after a subcutaneous injection of 10 mg kg-1. Tilmicosin was extensively secreted into milk, reaching a maximum concentration of 11.6 micrograms ml-1 and having a large AUCmilk/AUCserum ratio of approximately 12:1. Tilmicosin was detectable in milk for 11 days after a single subcutaneous dose.
Abdel Rahman, M. S., M. M. Fahmy, M. A. Hassanain, A. S. Nagwa, and K. M. Omnaia,
"Performance of serodiagnosis in sheep infested with or vaccinated against some species of Trichostrongylidae worms using Staphylococcus aureus protein A Cowan I Strain",
Vet.Med.J.Giza., vol. 45, issue 3, pp. 377-388., 1997.
Abdel Rahman, M. S., M. M. Fahmy, M. A. Hassanain, A. S. Nagwa, and K. M. Omnaia,
"Performance of serodiagnosis in sheep infested with or vaccinated against some species of Trichostrongylidae worms using Staphylococcus aureus protein A Cowan I Strain. ",
Vet.Med.J.Giza., vol. 45, issue 3, pp. 377-388., 1997.
Hanafy Ahmed, A. H., N. F. Kheir, and N. B. Talaat,
"Physiological studies on reducing the accumulation of nitrate in jew’s mallow (Corchorus olitorius L.) and radish (Raphanus sativus L.) plants.",
Bull. Fac. of Agric., Univ. of Cairo, vol. 48, issue 1, pp. 25-64., 1997.