BACKGROUND: Atrial fibrillation is the most commonly encountered arrhythmia. Several antiarrhythmic agents are effective in restoring and maintaining sinus rhythm.

AIM OF THE WORK: To compare the efficacy and rapidity of conversion of recent onset atrial fibrillation using oral propafenone versus intravenous infusion of amiodarone.

METHODS: The study included 200 patients with recent onset atrial fibrillation. Patients were equally divided into 2 groups; group A where intravenous infusion amiodarone was given and group B where oral propafenone was administrated. The effectiveness and the time needed for conversion of atrial fibrillation to sinus rhythm were compared in both groups.

RESULTS: The success of conversion of atrial fibrillation to sinus rhythm was 83% in group A and 85% in group B, p-value = 0.699. The time elapsed from drug administration till conversion of atrial fibrillation was 9.07 ± 5.04 hours in group A versus 3.9 ± 1.54 hours in group B, p-value = 0.001. In both groups, patients who showed failed conversion had a significantly larger left atrial diameter and a significantly higher high sensitivity C-reactive protein (hsCRP) level.

CONCLUSION: Oral propafenone was faster than parenteral amiodarone in the conversion of recent onset atrial fibrillation to sinus rhythm. Patients with failed conversion had a bigger left atrial diameter and a higher hsCRP when compared to patients with successful conversion.

The landscape of chronic liver disease in Egypt has drastically changed over the past few decades. The prevalence of metabolic-associated fatty liver disease (MAFLD) has risen to alarming levels. Despite the magnitude of the problem, no regional guidelines have been developed to tackle this disease. This document provides the clinical practice guidelines of the key Egyptian opinion leaders on MAFLD screening, diagnosis, and management, and covers various aspects in the management of MAFLD. The document considers our local situations and the burden of clinical management for the healthcare sector and is proposed for daily clinical practical use. Particular reference to special groups was done whenever necessary.

The current work reported the first synthesis of 4H-pyran derivatives via one pot reaction of dimedone, malononitrile and aromatic aldehydes under electrochemical (EC) synthesis conditions in deep eutectic solvents (DES). The effects of different experimental factors like; solvent, electrodes, supporting electrolytes, temperature and reaction time were studied to optimize the reaction conditions in order to maximize the products yield. The reaction proceeded completely using different substituted aldehydes except for hydroxybenzaldehydes where oxidation seems to hinder the formation of the target reaction product. Combining EC and DES afforded the pyran derivatives in high yields within short reaction times and in highly pure forms. Moreover, the use of DES eliminated the need for supporting electrolyte. The DES have been recycled two times without a significant loss in the catalytic activity. The procedure was highly efficient, catalyst-free and eco-friendly as evident from the calculations of the green chemistry metrics.