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2013
Mohareb, R. M., and A. A. Fahmy, "CYTOTOXICITY OF NOVEL 4,5,6,7-TETRAHYDRO BENZO[b]THIOPHENE DERIVATIVES AND THEIR USES AS ANTI-LEISHMANIAL AGENTS", Eur. Chem. Bull. , vol. 2, issue 8, pp. 545-553, 2013.
and, M. R. M., and A. G. A. Fahmy, "CYTOTOXICITY OF NOVEL 4,5,6,7-TETRAHYDROBENZO[ b]THIOPHENE DERIVATIVES AND THEIR USES AS ANTI-LEISHMANIAL AGENTS", Eur. Chem. Bull. , vol. 2(8), pp. 545-553, 2013.
Mohareb, R. M., S. M. Sherif, and A. abou Elkair, "Design, Synthesis and Molecular Modeling Studies of Some Heterocyclic Compounds Derived from the Suzuki-coupling of 6-bromo-1,3,4-oxadiazine Together with their Antitumor and Anti-leishmanial Evaluations", Current Organic Chemistry17, vol. 17, pp. 1910-1918, 2013. summary.docx
Mohareb, R. M., N. N. E. El-Sayed, and M. A. Abd El Aziz, "The Knoevenagel reactions of pregnenolone with cyanomethylene reagents: Synthesis of thiophene, thieno[2,3-b]pyridine, thieno[3,2-d]isoxazole derivatives of pregnenolone and their in vitro cytotoxicity towards tumor and normal cell lines", Steroids , vol. 78, pp. 1209–1219, 2013.
RM, M., E. - S. NN, and A. MA, "The Knoevenagel reactions of pregnenolone with cyanomethylene reagents: synthesis of thiophene, thieno[2,3-b]pyridine, thieno[3,2-d]isoxazole derivatives of pregnenolone and their in vitro cytotoxicity towards tumor and normal cell lines.", Steroids, vol. 78, issue 12-13, pp. 1209–1219, 2013. Abstract

The reaction of pregnenolone with either 2-aminoprop-1-ene-1,1,3-tricarbonitrile or 3-oxo-3-phenylpropanenitrile gave the Knoevenagel condensation products 3 and 6, respectively. Separation of the E and Z isomeric compounds of 3 and 6 together with their structure elucidation were carried out. Some chemical transformations of the latter products were carried out and the cytotoxicity of the newly obtained products was evaluated against some cancer cell lines and a human normal cell line. The results indicated that compounds 15, 17a, 18 and 20e among the tested compounds showed the highest cytotoxicity against the cancer cell lines.

Mohareb, R. M., A. E. M. Abdallah, and M. A. Abdelaziz, "New approaches for the synthesis of pyrazole, thiophene, thieno[2,3-b]pyridine, and thiazole derivatives together with their anti-tumor evaluations", Med Chem Res, vol. 22, pp. 1-13, 2013.
Mohareb, R. M., N. S. Abbas, and R. A. Ibrahim, "New Approaches for the Synthesis of Thiophene Derivatives with Anti-tumor Activities", Acta Chim. Slov. , pp. 60583–594, 2013.
Mohareb, R. M., N. A. Abas, and R. A. Ibrahim, "New approaches for The Synthesis of Thiophene Derivatives with Anti-tumor Activities", Acta Chemica Solvacia, vol. 60, pp. 583-594 , 2013.
Mohareb, R. M., and M. A. Abd El Aziz, "Reactions of Cyclohexanone with cyanoacetylhydrazine: Synthesis of indole, pyran, oxazine, pyrazole, thiophene and their fused derivatives with anti-tumor activities", Chemistry of Heterocyclic compounds, vol. 49, pp. 1212-1223, 2013.
Mohareb, R. M., and M. A. Abd El Aziz, "SUBSTITUTED 4,5,6,7-TETRAHYDROINDOLES AND THEIR FUSED DERIVATIVES. SYNTHESIS AND CYTOTOXIC ACTIVITY TOWARDS TUMOR AND NORMAL HUMAN CELL LINES", Chemistry of Heterocyclic Compounds, vol. 49, issue 8, pp. 1212-1223, 2013. summary.docx
WARDAKHAN, W. A. G. N. A. T. W. A. H. B. A., N. A. H. E. D. N. A. S. S. E. R. E. I. D. EL-SAYED, and R. M. Mohareb, "Synthesis and anti-tumor evaluation of novel hydrazide and hydrazide-hydrazone derivatives", Acta pharmaceutica, vol. 63, pp. 45–57, 2013. Abstract

The reaction of cyclopentanone with cyanoacetylhydrazine
gave 2-cyano-2-cyclopentylideneacetohydrazide (1).
Treatment of compound 1 with elemental sulphur in the
presence of triethylamine afforded 2-amino-5,6-dihydro-
-4H-cyclopenta[b]thiophene-3-carbohydrazide (2), which
in-turn formed the corresponding intermediate diazonium
salt. The latter was coupled with either ethyl cyanoacetate
or ethyl acetoacetate to form 2-cyano-2-(3-(hydrazinecarbonyl)-
5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)hydrazono)
acetate (3) and ethyl 2-(2-(3-(hydrazinecarbonyl)-5,6-dihydro-
4H-cyclopenta[b]thiophen-2-yl)hydrazono)-3-oxobutanoate
(4), respectively. On the other hand, the reaction of
compound 1 with either benzaldehyde or acetophenone
afforded N’-benzylidene-2-cyano-2-cyclopentylideneacetohydrazide
(7) and 2-cyano-2-(2-cyclopentylidene)phenylacetohydrazide
(10), respectively. Moreover, compound
1 was used to synthesize 2-cyano-2-cyclopentylidene-
N'-(arylthiazol-2(3H)-ylidene)acetohydrazides
(6a,b), 2-(2-benzylidenecyclopentylidene)-2-cyanoacetohydrazide
(8), 2-amino-N'-benzylidene-5,6-dihydro-4H-
-cyclopenta[b]thiophene-3-carbohydrazide (9), 2-cyano-
-2-(2-(2-phenylhydrazono)cyclopentylidene)acetohydrazide
(11), N'-(1-chloropropan-2-ylidene)-2-cyano-2-cyclopentylideneacetohydrazide
(12), and 2-cyclopentylidene-3-
-(3,5-disubstituted-1H-pyrazol-1-yl)-3-oxopropanenitriles
(13a,b) through its reaction with the respective reagents.
Antitumor evaluation of the newly synthesized compounds
against the three human tumor cells lines, namely,
breast adenocarcinoma (MCF-7), non-small cell lung
cancer (NCI-H460) and CNS cancer (SF-268) showed that
some of the described compounds exhibited higher inhibitory
effects towards the three tumor cell lines than the
reference compound doxorubicin.

Wardakhan, W. W., N. N. El-Sayed, and R. M. Mohareb, "Synthesis and anti-tumor evaluation of novel hydrazide and hydrazide-hydrazone derivatives", Acta Pharmaceutica, vol. 63, pp. 45- 57, 2013.
Mohareb, R. M., A. E. M. Abdallah, M. H. E. Helal[, and H. A. Mohammed, "SYNTHESIS AND ANTIMICROBIAL EVALUATIONS OF NEW BIOACTIVE DYES AND THEIR CYCLIZED DERIVATIVES SYNTHESIZED FROM 4,5,6,7-TETRAHYDROBENZO[b]-THIOPHENE", Eur. Chem. Bull. , vol. 2, issue 9, pp. 618-628, 2013.
Mohareb, R. M., A. E. M. Abdallah, M. H. E. Helal[, and H. A. Mohammed, "SYNTHESIS AND ANTIMICROBIAL EVALUATIONS OF NEW BIOACTIVE DYES AND THEIR CYCLIZED DERIVATIVES SYNTHESIZED FROM 4,5,6,7-TETRAHYDROBENZO[b]-THIOPHENE", Eur. Chem. Bull. , vol. 2, issue 9, pp. 618-628, 2013.
Mohareb, R. M., A. E. M. Abdallah, M. H. E. Helal, H. Allah, and N. A. Mohammed, "SYNTHESIS AND ANTIMICROBIAL EVALUATIONS OF NEW BIOACTIVE DYES AND THEIR CYCLIZED DERIVATIVES SYNTHESIZED FROM 4,5,6,7-TETRAHYDROBENZO[b]-THIOPHENE", Eur Chem. Bull. , vol. 2(9) , pp. 618-628, 2013.
Mohamed, F. A., and R. M. Mohareb, "Synthesis and applications of new bifunctional dyes bis (monochlorotriazine) based on tetrahydrobenzo[b]thiophene moiety", Pigment & Resin Technology, vol. 42, issue 4, pp. 264–270, 2013.
Ali, F., and R. M. Mohareb, "Synthesis and applications of new bifunctional dyes bis (monochlorotriazine) based on tetrahydrobenzo[b]thiophene moiety", Pigment and Resin technology , vol. 24, pp. 264-270 , 2013.
Fleita, D. H., O. K. Sakka, and R. M. Mohareb, "Synthesis, Structure Activity Relationships and Biological Activity Evaluation of Novel Spirocyclic Thiazolidin-4-ones as Potential Anti-Breast Cancer and Epidermal Growth Factor Receptor Inhibitors", Drug Research, vol. 63, pp. 1-8, 2013.
Fleita, D. H., O. El-Sakka, and R. M. Mohareb, "Synthesis, Structure Activity Relationships and Biological Activity Evaluation of Novel Spirocyclic Thiazolidin-4-ones as Potential Anti-Breast Cancer and Epidermal Growth Factor Receptor Inhibitors", Drug Discovery , vol. 63, pp. 1-8, 2013.
2012
Wardakhan, W. W., S. M. Sherif, R. M. Mohareb, and A. S. Abouzied, "- The reaction of cyanoacetylhdrazine with furan-2-aldehyde: novel synthesis of thiophene, azole, azine and coumarin derivatives and their antitumor evaluation", International J. of Organic Chem. , vol. 2, pp. 321-331, 2012.
Mohareb, R. M., and F. O. Al-Farouk, "Anti-Tumor and Anti-Leishmanial Evaluations of Novel Thiophen Derivatives Derived from the Reaction of Cyclopentanone with Elemental Sulphur and Cyano-Methylene Reagents", Current Organic Chemistry: Current Research , vol. 1, pp. 1-6, 2012.
Mohareb, R. M., "Conducting Scientific Research: Research Hypothesis and Null Hypothesis", Current Organic Chemistry: Current Research , vol. 2, pp. 1-3, 2012.
Mohareb, R. M., W. W. Wardakhan, G. A. Elmegeed, and R. S. Ashour, "Heterocyclizations of Pregnenolone: Novel synthesis of thiosemicarbazone, thiophene, thiazole, thieno[2,3-b]pyridine derivatives and their cytotoxicity evaluations", Steroids , vol. 77, pp. 1560–1569, 2012.
Mohareb, R. M., and E. M. Samir, "The Reaction of Cyanoacetylhydrazine with Chloroacetone: Synthesis of 1,2,4-Triazine, 1,3,4-Oxadiazine and Their Fused Derivatives with Antitumor Activities", Open Journal of Medicinal Chemistry, vol. 2, pp. 1-9, 2012.
Mohareb, R. M., and F. Al-Omran, "Reaction of Pregnenolone with cyanoacetylhdrazine: Novel synthesis of hydrazide-hydrazone, pyrazole, pyridine, thiazole, thiophene derivatives and their cytotoxicity evaluations", Steroids , vol. 77, pp. 1551–1559, 2012.
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