Mohareb, R. M., and A. A. Fahmy,
"CYTOTOXICITY OF NOVEL 4,5,6,7-TETRAHYDRO BENZO[b]THIOPHENE DERIVATIVES AND THEIR USES AS ANTI-LEISHMANIAL AGENTS",
Eur. Chem. Bull. , vol. 2, issue 8, pp. 545-553, 2013.
and, M. R. M., and A. G. A. Fahmy,
"CYTOTOXICITY OF NOVEL 4,5,6,7-TETRAHYDROBENZO[ b]THIOPHENE DERIVATIVES AND THEIR USES AS ANTI-LEISHMANIAL AGENTS",
Eur. Chem. Bull. , vol. 2(8), pp. 545-553, 2013.
Mohareb, R. M., S. M. Sherif, and A. abou Elkair,
"Design, Synthesis and Molecular Modeling Studies of Some Heterocyclic Compounds Derived from the Suzuki-coupling of 6-bromo-1,3,4-oxadiazine Together with their Antitumor and Anti-leishmanial Evaluations",
Current Organic Chemistry17, vol. 17, pp. 1910-1918, 2013.
RM, M., E. - S. NN, and A. MA,
"The Knoevenagel reactions of pregnenolone with cyanomethylene reagents: synthesis of thiophene, thieno[2,3-b]pyridine, thieno[3,2-d]isoxazole derivatives of pregnenolone and their in vitro cytotoxicity towards tumor and normal cell lines.",
Steroids, vol. 78, issue 12-13, pp. 1209–1219, 2013.
AbstractThe reaction of pregnenolone with either 2-aminoprop-1-ene-1,1,3-tricarbonitrile or 3-oxo-3-phenylpropanenitrile gave the Knoevenagel condensation products 3 and 6, respectively. Separation of the E and Z isomeric compounds of 3 and 6 together with their structure elucidation were carried out. Some chemical transformations of the latter products were carried out and the cytotoxicity of the newly obtained products was evaluated against some cancer cell lines and a human normal cell line. The results indicated that compounds 15, 17a, 18 and 20e among the tested compounds showed the highest cytotoxicity against the cancer cell lines.
Mohareb, R. M., A. E. M. Abdallah, and M. A. Abdelaziz,
"New approaches for the synthesis of pyrazole, thiophene, thieno[2,3-b]pyridine, and thiazole derivatives together with their anti-tumor evaluations",
Med Chem Res, vol. 22, pp. 1-13, 2013.
Mohareb, R. M., and M. A. Abd El Aziz,
"Reactions of Cyclohexanone with cyanoacetylhydrazine: Synthesis of indole, pyran, oxazine, pyrazole, thiophene and their fused derivatives with anti-tumor activities",
Chemistry of Heterocyclic compounds, vol. 49, pp. 1212-1223, 2013.
Mohareb, R. M., and M. A. Abd El Aziz,
"SUBSTITUTED 4,5,6,7-TETRAHYDROINDOLES AND THEIR FUSED DERIVATIVES. SYNTHESIS AND CYTOTOXIC ACTIVITY TOWARDS TUMOR AND NORMAL HUMAN CELL LINES",
Chemistry of Heterocyclic Compounds, vol. 49, issue 8, pp. 1212-1223, 2013.
WARDAKHAN, W. A. G. N. A. T. W. A. H. B. A., N. A. H. E. D. N. A. S. S. E. R. E. I. D. EL-SAYED, and R. M. Mohareb,
"Synthesis and anti-tumor evaluation of novel hydrazide and hydrazide-hydrazone derivatives",
Acta pharmaceutica, vol. 63, pp. 45–57, 2013.
AbstractThe reaction of cyclopentanone with cyanoacetylhydrazine
gave 2-cyano-2-cyclopentylideneacetohydrazide (1).
Treatment of compound 1 with elemental sulphur in the
presence of triethylamine afforded 2-amino-5,6-dihydro-
-4H-cyclopenta[b]thiophene-3-carbohydrazide (2), which
in-turn formed the corresponding intermediate diazonium
salt. The latter was coupled with either ethyl cyanoacetate
or ethyl acetoacetate to form 2-cyano-2-(3-(hydrazinecarbonyl)-
5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)hydrazono)
acetate (3) and ethyl 2-(2-(3-(hydrazinecarbonyl)-5,6-dihydro-
4H-cyclopenta[b]thiophen-2-yl)hydrazono)-3-oxobutanoate
(4), respectively. On the other hand, the reaction of
compound 1 with either benzaldehyde or acetophenone
afforded N’-benzylidene-2-cyano-2-cyclopentylideneacetohydrazide
(7) and 2-cyano-2-(2-cyclopentylidene)phenylacetohydrazide
(10), respectively. Moreover, compound
1 was used to synthesize 2-cyano-2-cyclopentylidene-
N'-(arylthiazol-2(3H)-ylidene)acetohydrazides
(6a,b), 2-(2-benzylidenecyclopentylidene)-2-cyanoacetohydrazide
(8), 2-amino-N'-benzylidene-5,6-dihydro-4H-
-cyclopenta[b]thiophene-3-carbohydrazide (9), 2-cyano-
-2-(2-(2-phenylhydrazono)cyclopentylidene)acetohydrazide
(11), N'-(1-chloropropan-2-ylidene)-2-cyano-2-cyclopentylideneacetohydrazide
(12), and 2-cyclopentylidene-3-
-(3,5-disubstituted-1H-pyrazol-1-yl)-3-oxopropanenitriles
(13a,b) through its reaction with the respective reagents.
Antitumor evaluation of the newly synthesized compounds
against the three human tumor cells lines, namely,
breast adenocarcinoma (MCF-7), non-small cell lung
cancer (NCI-H460) and CNS cancer (SF-268) showed that
some of the described compounds exhibited higher inhibitory
effects towards the three tumor cell lines than the
reference compound doxorubicin.
Mohareb, R. M., A. E. M. Abdallah, M. H. E. Helal[, and H. A. Mohammed,
"SYNTHESIS AND ANTIMICROBIAL EVALUATIONS OF NEW BIOACTIVE DYES AND THEIR CYCLIZED DERIVATIVES SYNTHESIZED FROM 4,5,6,7-TETRAHYDROBENZO[b]-THIOPHENE",
Eur. Chem. Bull. , vol. 2, issue 9, pp. 618-628, 2013.
Mohareb, R. M., A. E. M. Abdallah, M. H. E. Helal[, and H. A. Mohammed,
"SYNTHESIS AND ANTIMICROBIAL EVALUATIONS OF NEW BIOACTIVE DYES AND THEIR CYCLIZED DERIVATIVES SYNTHESIZED FROM 4,5,6,7-TETRAHYDROBENZO[b]-THIOPHENE",
Eur. Chem. Bull. , vol. 2, issue 9, pp. 618-628, 2013.
Mohareb, R. M., A. E. M. Abdallah, M. H. E. Helal, H. Allah, and N. A. Mohammed,
"SYNTHESIS AND ANTIMICROBIAL EVALUATIONS OF NEW BIOACTIVE DYES AND THEIR CYCLIZED DERIVATIVES SYNTHESIZED FROM 4,5,6,7-TETRAHYDROBENZO[b]-THIOPHENE",
Eur Chem. Bull. , vol. 2(9) , pp. 618-628, 2013.