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Sabry, D., O. O. Abdelaleem, E. M. Hefzy, A. A. Ibrahim, T. I. Ahmed, E. A. Hassan, N. D. Abdel-Hameed, and M. A. F. Khalil, "Interplay Between Helicobacter pylori Infection, Interleukin-11, and Leukemia Inhibitory Factor in Gastric Cancer Among Egyptian Patients.", Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, vol. 38, issue 11, pp. 517-525, 2018 Nov. Abstract

Helicobacter pylori is a ubiquitous Gram-negative bacterium, that is responsible for gastric mucosal inflammation. It is the most common risk factor for gastric cancer (GC). The current study aimed to investigate the association between interleukin-11 (IL-11) and leukemia inhibitory factor (LIF) levels among H. pylori-infected Egyptian patients with gastritis and GC. One hundred forty-seven patients with gastric lesions were endoscopically biopsied and assessed using rapid urease test and immunohistochemistry. Quantitative real-time polymerase chain reaction was done for the detection of H. pylori load in gastric biopsies and detection of LIF as well as IL-11 relative gene expression. The mean values of H. pylori load, LIF, and IL-11 were significantly elevated in GC patients compared to gastritis group (P < 0.0001). A positive significant correlation was detected between mucosal levels of LIF, IL-11, and H. pylori load in both groups. Both LIF and IL-11 had the same pattern of expression in gastric tissues with different types of gastritis and different types and grades of gastric carcinoma. This report could clarify the molecular events associated with the immune response against H. pylori infection and H. pylori-associated pathology. Therefore, development of immunotherapy strategies against H. pylori-induced cytokines becomes inevitable.

Mostafa-Hedeab, G., D. Sabry, G. M. Abdelaziz, M. Ewaiss, N. Adli, and W. Fathy, "Influence of Vitamin D Receptor Gene Polymorphisms on Response to Pegylated Interferon in Chronic Hepatitis B Egyptian Patients ", Reports of Biochemistry & Molecular Biology , vol. 6, issue 2, pp. 186-196, 2018. rbmb.pdf
Fouad, R., M. Abdo, H. G. E. deen, D. Sabry, Mira Atef, R. Ahmed, and N. Zayed, "Influence of delta virus infection on the virologic status in Egyptian patients with chronic Hepatitis B virus genotype D", J Med Virol., vol. 88, issue 5, pp. 837-42, 2016.
Omar, R. F., R. Ahmed, D. Sabry, Mahmoud Abdel Alim, Mira Atef, and N. Zayed, "Influence of Delta Virus Infection on the Clinical Spectrum, Serologic and Virologic Status in Chronic Hepatitis B Virus Genotype D", HEPATOLOGY, WILEY-BLACKWELL, 60, pp. 971A-972A, 2014.
Abdelfattah, D. S., R. Sayed, G. Mostafa-Hedeab, and H. H. M. Ali, "In Vitro Characterization and Evaluation of Silver Nanoparticles Cytotoxicity on Human “Liver and Breast” Cancer Cells Versus Normal Melanocytes ", The Egyptian journal of histology, vol. 42, issue 3, pp. 755-766, 2019.
Abdel Aziz, M. T., D. Sabry, M. A. S. Al-Ghussein, A. M. A. Soliman, and A. A. Hassan, "IN VITRO AND IN VIVO EVALUATION ACTIVITIES OF EACH MESENCHYMAL STEM CELLS, DOXORUBICIN AND LPS OR COMBINED ON BREAST CARCINOMA", WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, vol. 3, issue 8, pp. 157-176, 2014.
Esmat, G., M. E. Raziky, A. Elsharkawy, D. Sabry, A. Mohamed Hassany, A. Ahmed, N. Assem, M. El Kassas, and W. D, "Impact of vitamin D supplementation on sustained virological response in chronic hepatitis C genotype 4 patients treated by pegylated interferon/ribavirin", Journal of Interferon & Cytokine Research, vol. 35, issue 1, pp. 49-54, 2015.