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Nadia Abdelaaty Abdelkader, Soha Saoud Abdelmoniem, D. Sabry, Amin Mohamad Abdelbaky, Maram M Mahdy, E. Zaky, and W. Elsayed, "Vitamin D and IL28B genotyping as predictors for antiviral therapy: a retrospective study in Egyptian HCV genotype 4a", Tropical Journal of Pharmaceutical Research, vol. 13, issue 10, pp. 1725-1732, 2014.
Nadia Abdelaaty Abdelkader, D. Sabry, Mohamed Al-Ghussein, Hany Mansour Dabbous, and E. H. Allam, "Correlation between Vitamin D Receptor and Monocyte Chemotactic Protein-1 Polymorphisms and Spontaneous Bacterial Peritonitis in Decompensated Liver Disease", Journal of Gastroenterology and Hepatology Research, vol. 4, issue 11, pp. 1815-1820, 2015.
Naga, M., M. Amin, D. Algendy, A. Elbadry, M. Fawzi, A. Foda, S. Esmat, D. Sabry, L. Rashed, S. Gabal, et al., " Dina Sabry [HTML] from Low-density lipoprotein receptor genetic polymorphism in chronic hepatitis C virus Egyptian patients affects treatment response", World journal of gastroenterology: WJG, vol. 21, issue 39, pp. 11141, 2015.
Nassar, W., M. El-Ansary, D. Sabry, M. A. Mostafa, T. Fayad, E. Kotb, M. Temraz, A. - N. Saad, W. Essa, and H. Adel, "Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases.", Biomaterials research, vol. 20, pp. 21, 2016. Abstract

BACKGROUND: Bio-products from stem/progenitor cells, such as extracellular vesicles, are likely a new promising approach for reprogramming resident cells in both acute and chronic kidney disease. Forty CKD patients stage III and IV (eGFR 15-60 mg/ml) have been divided into two groups; twenty patients as treatment group "A" and twenty patients as a matching placebo group "B". Two doses of MSC-derived extracellular vesicles had been administered to patients of group "A". Blood urea, serum creatinine, urinary albumin creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) have been used to assess kidney functions and TNF-α, TGF-β1 and IL-10 have been used to assess the amelioration of the inflammatory immune activity.

RESULTS: Participants in group A exhibited significant improvement of eGFR, serum creatinine level, blood urea and UACR. Patients of the treatment group "A" also exhibited significant increase in plasma levels of TGF-β1, and IL-10 and significant decrease in plasma levels of TNF-α. Participants of the control group B did not show significant improvement in any of the previously mentioned parameters at any time point of the study period.

CONCLUSION: Administration of cell-free cord-blood mesenchymal stem cells derived extracellular vesicles (CF-CB-MSCs-EVs) is safe and can ameliorate the inflammatory immune reaction and improve the overall kidney function in grade III-IV CKD patients.