Publications

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2005
Aziz, M. T. A., M. F. El-Asmar, T. Mostafa, H. Atta, M. A. A. Wassef, H. H. Fouad, N. K. Roshdy, L. A. Rashed, and D. Sabry, "Effects of nitric oxide synthase and heme oxygenase inducers and inhibitors on molecular signaling of erectile function", Journal of Clinical Biochemistry and Nutrition, vol. 37, no. 3: 日本酸化ストレス学会 JCBN 事務局, pp. 103–111, 2005. Abstract
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2007
Aziz, A. E., M. Talaat, F. M. Al-Asmar, T. Mostafa, H. Atta, L. Rashed, D. Sabry, S. Ashour, and A. T. Abdel Aziz, "Assessment of heme oxygenase-1 (HO-1) activity in the cavernous tissues of sildenafil citrate-treated rats", Asian journal of andrology, vol. 9, no. 3: Wiley Online Library, pp. 377–381, 2007. Abstract
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Abdel Aziz, M. T., T. Mostafa, H. Atta, L. Rashed, S. A. Marzouk, E. M. Obaia, D. Sabry, A. A. Hassouna, A. M. El-Shehaby, and A. T. Abdel Aziz, "Oral phosphodiesterase-5 inhibitors: effect of heme oxygenase inhibition on cGMP signalling in rat cavernous tissue", Andrologia, vol. 39, no. 2: Wiley Online Library, pp. 66–70, 2007. Abstract
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Aziz, A. E., M. Talaat, M. F. El-Asmer, T. Mostafa, S. Mostafa, H. Atta, M. Abdel Aziz Wassef, H. Fouad, L. Rashed, D. Sabry, et al., "ORIGINAL RESEARCH—BASIC SCIENCE: Heme Oxygenase vs. Nitric Oxide Synthase in Signaling Mediating Sildenafil Citrate Action", The journal of sexual medicine, vol. 4, no. 4ii: Wiley Online Library, pp. 1098–1107, 2007. Abstract
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Abdel Aziz, M. T., H. M. Atta, S. Mahfouz, H. H. Fouad, N. K. Roshdy, H. H. Ahmed, L. A. Rashed, D. Sabry, A. A. Hassouna, and N. M. Hasan, "Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis", Clinical biochemistry, vol. 40, no. 12: Elsevier, pp. 893–899, 2007. Abstract
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2008
Abdel, A. M. T., F. M. El-Asmar, T. Mostafa, H. Atta, H. H. Fouad, N. K. Roshdy, L. A. Rashed, E. A. Obaia, D. A. Sabry, A. A. T. Abdel, et al., "Effect of hemin and carbon monoxide releasing molecule (CORM-3) on cGMP in rat penile tissue.", The journal of sexual medicine, vol. 5, no. 2, pp. 336–343, 2008. Abstract
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Aziz, M., T. Mostafa, H. Atta, L. Rashed, S. A. Marzouk, E. M. Obaia, D. Sabry, A. A. Hassouna, A. M. El-Shehaby, and A. A. T. Aziz, "The role of PDE5 inhibitors in heme oxygenase–cGMP relationship in rat cavernous tissues", The Journal of Sexual Medicine, vol. 5, no. 7: Wiley Online Library, pp. 1636–1645, 2008. Abstract
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2009
Aziz, A. E., M. Talaat, E. Asmer, M. Farid, T. Mostafa, H. Atta, S. Mahfouz, H. Fouad, L. Rashed, D. Sabry, et al., "Effects of Losartan, HO-1 Inducers or HO-1 Inhibitors on Erectile Signaling in Diabetic Rats", The journal of sexual medicine, vol. 6, no. 12: Wiley Online Library, pp. 3254–3264, 2009. Abstract
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Abdel Aziz, M. T., T. Mostafa, H. Atta, M. A. Wassef, H. H. Fouad, L. A. Rashed, and D. Sabry, "Putative role of carbon monoxide signaling pathway in penile erectile function", The journal of sexual medicine, vol. 6, no. 1: Wiley Online Library, pp. 49–60, 2009. Abstract
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2010
Haleem, A. M., A. A. El Singergy, D. Sabry, H. M. Atta, L. A. Rashed, C. R. Chu, M. T. El Shewy, A. Azzam, and M. A. T. Aziz, "The Clinical Use of Human Culture–Expanded Autologous Bone Marrow Mesenchymal Stem Cells Transplanted on Platelet-Rich Fibrin Glue in the Treatment of Articular Cartilage Defects A Pilot Study and Preliminary Results", Cartilage, vol. 1, no. 4: SAGE Publications, pp. 253–261, 2010. Abstract
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Abdel Aziz, M. T., S. El-Haggar, T. Mostafa, H. Atta, H. Fouad, S. Mahfouz, L. Rashed, D. Sabry, A. Senbel, and G. A. Ali, "Effect of mesenchymal stem cell penile transplantation on erectile signaling of aged rats", Andrologia, vol. 42, no. 3: Wiley Online Library, pp. 187–192, 2010. Abstract
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Abdel Aziz, M. T., T. Mostafa, H. Atta, O. Kamal, M. Kamel, H. Hosni, L. Rashed, D. Sabry, and F. Waheed, "Heme oxygenase enzyme activity in seminal plasma of oligoasthenoteratozoospermic males with varicocele", Andrologia, vol. 42, no. 4: Wiley Online Library, pp. 236–241, 2010. Abstract
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El-Menoufy, H., L. A. A. Aly, M. T. A. Aziz, H. M. Atta, N. K. Roshdy, L. A. Rashed, and D. Sabry, "The role of bone marrow-derived mesenchymal stem cells in treating formocresol induced oral ulcers in dogs", Journal of oral pathology & medicine, vol. 39, no. 4: Wiley Online Library, pp. 281–289, 2010. Abstract
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2011
Roshdy, N. K., L. A. Rashed, D. Sabry, A. A. Hassouna, and F. M. Taha, Efficacy of mesenchymal stem cells in suppression of hepatocarcinorigenesis in rats: possible role of Wnt signaling, , 2011. Abstract
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Mokbel, A. N., O. S. El Tookhy, A. A. Shamaa, L. A. Rashed, D. Sabry, and A. M. Elsayed, "Homing and reparative effect of intra-articular injection of autologus mesenchymal stem cells in osteoarthritic animal model", BMC musculoskeletal disorders, vol. 12, no. 1: BioMed Central Ltd, pp. 259, 2011. Abstract
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2013
A, F., S. D, A. R, K. M, Allah SA, Marzouk S, A. M, Abd El Aziz R, El Badri A, K. H, et al., "Comparative diagnostic study of biomarkers using FibroMax™ and pathology for prediction of liver steatosis in patients with chronic hepatitis C virus infection: an Egyptian study.", Int J Gen Med, vol. 12, issue 6, pp. 127-34, 2013.
H, F., Raziky MS, Aziz RA, S. D, Aziz GM, Ewais M, and S. AR., "Dendritic cell co-stimulatory and co-inhibitory markers in chronic HCV: an Egyptian study.", World journal of gastroenterology: WJG, vol. 19, issue 43, pp. 7711-8, 2013.
MT1, A. A., K. HM, E. H. A, R. NK, H. A. A. T. A. W. I. F. Rashed LA, Sabry D, Hassouna AA, T. F, and A. WI., "Effect of mesenchymal stem cells and a novel curcumin derivative on Notch1 signaling in hepatoma cell line.", Biomed Res Int, 2013. Abstract

This study was conducted to evaluate the effect of mesenchymal stem cells (MSCs) and a novel curcumin derivative (NCD) on HepG2 cells (hepatoma cell line) and to investigate their effect on Notch1 signaling pathway target genes. HepG2 cells were divided into HepG2 control group, HepG2 cells treated with MSC conditioned medium (MSCs CM), HepG2 cells treated with a NCD, HepG2 cells treated with MSCs CM and NCD, and HepG2 cells treated with MSCs CM (CM of MSCs pretreated with a NCD). Expression of Notch1, Hes1, VEGF, and cyclin D1 was assessed by real-time, reverse transcription-polymerase chain reaction (RT-PCR) in HepG2 cells. In addition, HepG2 proliferation assay was performed in all groups. Notch1 and its target genes (Hes1 and cyclin D1) were downregulated in all treated groups with more suppressive effect in the groups treated with both MSCs and NCD. Also, treated HepG2 cells showed significant decrease in cell proliferation rate. These data suggest that modulation of Notch1 signaling pathway by MSCs and/or NCD can be considered as a therapeutic target in HCC.

MA1, A., S. D, R. LA, A. WM, el-Ghobary MA, F. MS, F. HA, and Y. YA., "Short-term evaluation of autologous transplantation of bone marrow-derived mesenchymal stem cells in patients with cirrhosis: Egyptian study", Clin Transplant., vol. 27, issue 4, pp. 607-12, 2013. Abstract

Stem cell-based therapy has received attention as a possible alternative to organ transplantation. The aim of this study was to assess the safety and efficacy of autologous transplantation of bone marrow (BM)-derived stromal cells in post-HCV liver cirrhosis patients.
METHODOLOGY:
10 × 10(6) of isolated human bone marrow (HBM)-stromal cells in 10 mL normal saline were injected in the spleen of 20 patients with end-stage liver cirrhosis guided by the ultrasonography, and then patients were followed up on monthly basis for six months.
RESULTS:
A statistically significant decrease was detected in the total bilirubin, aspartate transaminase (AST), alanine transaminase (ALT) (p-value<0.01), prothrombin time (PT), and international normalized ratio (INR) levels (p-value<0.05), while a statistically significant increase in the albumin and PC (p-value<0.05) after follow-up.
CONCLUSION:
This study suggested the safety, feasibility, and efficacy of the intrasplenic injection of autologous BM stromal cells in improving liver function in Egyptian patients with cirrhosis.
© 2013 John Wiley & Sons A/S.

MT, A., El Ibrashy IN, M. DP, R. AM, W. MA, F. HH, A. HH, Sabry DA, Shawky HM, and H. RE., "Signaling mechanisms of a water soluble curcumin derivative in experimental type 1 diabetes with cardiomyopathy.", Diabetol Metab Syndr., vol. 12, issue 5, pp. 13, 2013.
2014
Elsetohy, K. A., M. A. S. Al-Ghussein, D. Sabry, A. M. Nada, A. A. Eldaly, and A. H. Wahba, "ARE RENALASE RS2576178 AND RS10887800 POLYMORPHISMS ASSOCIATED WITH PREGNANCY INDUCED HYPERTENSION?", WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, vol. 3, issue 8, pp. 177-192, 2014.
Abdelhamid, M., Y Sharaf, S. Bakhoum, D. Sabry, and A. Talaat, "Circulating EPCs predicts the occurrence of major adverse cardiac events and early adverse remodeling in patients with STEMI", EUROPEAN HEART JOURNAL, OXFORD UNIV PRESS, 35, pp. 651-651, 2014.
Sabry, D., A. Osama, N Idriss, and M. Magdy, "Comparative study between the effects of human CD34+ and rat bone marrow mesenchymal stem cells on amelioration of CCL4 induced liver fibrosis", FEBS JOURNAL, France WILEY-BLACKWELL, 281, pp. 222-222, 2014.
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