@article {36419, title = {Short-term evaluation of autologous transplantation of bone marrow-derived mesenchymal stem cells in patients with cirrhosis: Egyptian study}, journal = {Clin Transplant.}, volume = {27}, year = {2013}, pages = {607-12}, abstract = {

Stem cell-based therapy has received attention as a possible alternative to organ transplantation. The aim of this study was to assess the safety and efficacy of autologous transplantation of bone marrow (BM)-derived stromal cells in post-HCV liver cirrhosis patients.
METHODOLOGY:
10 {\texttimes} 10(6) of isolated human bone marrow (HBM)-stromal cells in 10 mL normal saline were injected in the spleen of 20 patients with end-stage liver cirrhosis guided by the ultrasonography, and then patients were followed up on monthly basis for six months.
RESULTS:
A statistically significant decrease was detected in the total bilirubin, aspartate transaminase (AST), alanine transaminase (ALT) (p-value\<0.01), prothrombin time (PT), and international normalized ratio (INR) levels (p-value\<0.05), while a statistically significant increase in the albumin and PC (p-value\<0.05) after follow-up.
CONCLUSION:
This study suggested the safety, feasibility, and efficacy of the intrasplenic injection of autologous BM stromal cells in improving liver function in Egyptian patients with cirrhosis.
{\textcopyright} 2013 John Wiley \& Sons A/S.

}, author = {Amin MA1 and Sabry D and Rashed LA and Aref WM and el-Ghobary MA and Farhan MS and Fouad HA and Youssef YA.} }