@article {125829,
	title = {Aryl hydrocarbon receptor (AhR) rs2066853 gene polymorphism association with infertile oligoasthenoteratozoospermic men and seminal oxidative stress.},
	journal = {Environmental science and pollution research international},
	year = {2017},
	month = {2017 Feb 04},
	abstract = {<p>This study aimed to assess the association between aryl hydrocarbon receptor (AhR) rs2066853 gene polymorphism with infertile oligoasthenoteratozoospermic (OAT) men and seminal oxidative stress (OS). A total of 170 Egyptian men were allocated according to their semen analysis into fertile normozoospermic controls (n~=~50) and infertile OAT men (n~=~120). They were subjected to history taking, clinical examination, semen analysis, estimation of seminal glutathione peroxidase (GPx), and malondialdehyde (MDA). AhR rs2066853 gene polymorphism was identified in the blood by PCR-RFLP. Comparing infertile OAT men with fertile controls, AhR rs2066853 genotypes showed decreased prevalence for wild homozygous genotype GG (35.8 vs 56\%) and for heterozygous genotype GA (17.5 vs 30\%) and an increased prevalence for homozygous genotype AA (46.7 vs 14\%). Distribution of alleles of AhR rs2066853 among OAT men compared with fertile men showed decreased prevalence of G allele (44.6 vs 71\%) and an increased prevalence of A allele (55.4 vs 29\%). Seminal MDA demonstrated significant increase whereas seminal GPx demonstrated significant decrease in cases with AA and GA/AA genotypes compared to cases with GG genotype. It is concluded that there is a significant association between AhR rs2066853 genotype polymorphism with decreased sperm parameters as well as increased seminal oxidative stress in infertile OAT men.</p>
},
	issn = {1614-7499},
	doi = {10.1007/s11356-017-8519-2},
	author = {Taymour Mostafa and Hanan Fouad and Nabil, Nashaat and Laila Rashed and Dina Sabry and Abougabal, Khadiga and Gendy, Bolis S}
}
