Publications

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2020
Ahmed, Y., R. S. Hussein, T. A. Basha, A. M. Khalifa, A. S. Ibrahim, A. S. Abdelmoaty, H. M. Abdella, and A. S. Fahmy, "Detecting liver fibrosis using a machine learning‐based approach to the quantification of the heart‐induced deformation in tagged MR images", NMR in Biomedicine, vol. 33, issue 1, pp. e4215, 2020. Abstract
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2019
Basha, T., and R. Nezafat, Method and apparatus for multi-slice imaging of T2-relaxation time, , jan # " 29", 2019. Abstract
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Nezafat, M., S. Nakamori, T. A. Basha, A. S. Fahmy, T. Hauser, and R. M. Botnar, "Imaging sequence for joint myocardial T 1 mapping and fat/water separation", Magnetic resonance in medicine, vol. 81, no. 1, pp. 486–494, 2019. Abstract
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Nezafat, M., S. Nakamori, T. A. Basha, A. S. Fahmy, T. Hauser, and R. M. Botnar, "Imaging sequence for joint myocardial T 1 mapping and fat/water separation", Magnetic resonance in medicine, vol. 81, issue 1, pp. 486-494, 2019. Abstract
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2018
Basha, T. A., M. C. Tang, C. Tsao, C. M. Tschabrunn, E. Anter, W. J. Manning, and R. Nezafat, "Improved dark blood late gadolinium enhancement (DB-LGE) imaging using an optimized joint inversion preparation and Tmagnetization preparation.", Magnetic resonance in medicine, vol. 79, issue 1, pp. 351-360, 2018 Jan. Abstract

PURPOSE: To develop a dark blood-late gadolinium enhancement (DB-LGE) sequence that improves scar-blood contrast and delineation of scar region.

METHODS: The DB-LGE sequence uses an inversion pulse followed by Tmagnetization preparation to suppress blood and normal myocardium. Time delays inserted after preparation pulses and T-magnetization-prep duration are used to adjust tissue contrast. Selection of these parameters was optimized using numerical simulations and phantom experiments. We evaluated DB-LGE in 9 swine and 42 patients (56 ± 14 years, 33 male). Improvement in scar-blood contrast and overall image quality was subjectively evaluated by two independent readers (1 = poor, 4 = excellent). The signal ratios among scar, blood, and myocardium were compared.

RESULTS: Simulations and phantom studies demonstrated that simultaneous nulling of myocardium and blood can be achieved by selecting appropriate timing parameters. The scar-blood contrast score was significantly higher for DB-LGE (P < 0.001) with no significant difference in overall image quality (P > 0.05). Scar-blood signal ratios for DB-LGE versus LGE were 5.0 ± 2.8 versus 1.5 ± 0.5 (P < 0.001) for patients, and 2.2 ± 0.7 versus 1.0 ± 0.4 (P = 0.0023) for animals. Scar-myocardium signal ratios were 5.7 ± 2.9 versus 6.3 ± 2.6 (P = 0.35) for patients, and 3.7 ± 1.1 versus 4.1 ± 2.0 (P = 0.60) for swine.

CONCLUSIONS: The DB-LGE sequence simultaneously reduces normal myocardium and blood signal intensity, thereby enhancing scar-blood contrast while preserving scar-myocardium contrast. Magn Reson Med 79:351-360, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Fahmy, A. S., U. Neisius, C. W. Tsao, S. Berg, E. Goddu, P. Pierce, T. A. Basha, L. Ngo, W. J. Manning, and R. Nezafat, "Gray blood late gadolinium enhancement cardiovascular magnetic resonance for improved detection of myocardial scar", Journal of Cardiovascular Magnetic Resonance, vol. 20, no. 1: BioMed Central, pp. 22, 2018. Abstract
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Basha, T. A., M. C. Tang, C. Tsao, C. M. Tschabrunn, E. Anter, W. J. Manning, and R. Nezafat, "Improved dark blood late gadolinium enhancement (DB-LGE) imaging using an optimized joint inversion preparation and T2 magnetization preparation", Magnetic resonance in medicine, vol. 79, no. 1, pp. 351–360, 2018. Abstract
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2017
Basha, T. A., M. Akçakaya, C. Liew, C. W. Tsao, F. N. Delling, G. Addae, L. Ngo, W. J. Manning, and R. Nezafat, "Clinical performance of high-resolution late gadolinium enhancement imaging with compressed sensing.", Journal of magnetic resonance imaging : JMRI, vol. 46, issue 6, pp. 1829-1838, 2017 Dec. Abstract

PURPOSE: To evaluate diagnostic image quality of 3D late gadolinium enhancement (LGE) with high isotropic spatial resolution (∼1.4 mm) images reconstructed from randomly undersampled k-space using LOw-dimensional-structure Self-learning and Thresholding (LOST).

MATERIALS AND METHODS: We prospectively enrolled 270 patients (181 men; 55 ± 14 years) referred for myocardial viability assessment. 3D LGE with isotropic spatial resolution of 1.4 ± 0.1 mmwas acquired at 1.5T using a LOST acceleration rate of 3 to 5. In a subset of 121 patients, 3D LGE or phase-sensitive LGE were acquired with parallel imaging with an acceleration rate of 2 for comparison. Two readers evaluated image quality using a scale of 1 (poor) to 4 (excellent) and assessed for scar presence. The McNemar test statistic was used to compare the proportion of detected scar between the two sequences. We assessed the association between image quality and characteristics (age, gender, torso dimension, weight, heart rate), using generalized linear models.

RESULTS: Overall, LGE detection proportions for 3D LGE with LOST were similar between readers 1 and 2 (16.30% vs. 18.15%). For image quality, readers gave 85.9% and 80.0%, respectively, for images categorized as good or excellent. Overall proportion of scar presence was not statistically different from conventional 3D LGE (28% vs. 33% [P = 0.17] for reader 1 and 26% vs. 31% [P = 0.37] for reader 2). Increasing subject heart rate was associated with lower image quality (estimated slope = -0.009 (P = 0.001)).

CONCLUSION: High-resolution 3D LGE with LOST yields good to excellent image quality in >80% of patients and identifies patients with LV scar at the same rate as conventional 3D LGE.

LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1829-1838.

Nezafat, M., I. T. Ramos, M. Henningsson, A. Protti, T. Basha, and R. M. Botnar, "Improved segmented modified Look-Locker inversion recovery T1 mapping sequence in mice.", PloS one, vol. 12, issue 11, pp. e0187621, 2017. Abstract

OBJECT: To develop and evaluate a 2D modified Look-Locker (MOLLI) for high-resolution T1 mapping in mice using a 3T MRI scanner.

MATERIALS AND METHODS: To allow high-resolution T1 mapping in mice at high heart rates a multi-shot ECG-triggered 2D MOLLI sequence was developed. In the proposed T1 mapping sequence the optimal number of sampling points and pause cardiac cycles following an initial adiabatic inversion pulse was investigated in a phantom. Seven native control and eight mice, 3 days post myocardial infarction (MI) after administration of gadolinium were scanned. Two experienced readers graded the visual T1 map quality.

RESULTS: In T1 phantoms, there were no significant differences (<0.4% error) between 12, 15 and 20 pause cardiac cycles (p = 0.1, 0.2 and 0.6 respectively) for 8 acquisition cardiac cycles for 600bpm in comparison to the conventional inversion recovery spin echo T1 mapping sequence for short T1's (<600 ms). Subsequently, all in-vivo scans were performed with 8 data acquisitions and 12 pause cardiac cycles to minimize scan time. The mean native T1 value of myocardium in control animal was 820.5±52 ms. The post-contrast T1 measured 3 days after MI in scar was 264±59 ms and in healthy myocardium was 512±62 ms. The Bland-Altman analysis revealed mean difference of only -1.06% of infarct size percentage between T1 maps and LGE.

CONCLUSIONS: A multi-shot 2D MOLLI sequence has been presented that allows reliable measurement of high spatial resolution T1 maps in mice for heart rates up to 600bpm.

Basha, T. A., M. Akcakaya, C. Liew, C. W. Tsao, F. N. Delling, G. Addae, L. Ngo, W. J. Manning, and R. Nezafat, "Clinical performance of high-resolution late gadolinium enhancement imaging with compressed sensing", Journal of Magnetic Resonance Imaging, vol. 46, no. 6, pp. 1829–1838, 2017. Abstract
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Nezafat, M., I. T. Ramos, M. Henningsson, A. Protti, T. Basha, and R. M. Botnar, "Improved segmented modified Look-Locker inversion recovery T1 mapping sequence in mice", PloS one, vol. 12, no. 11: Public Library of Science, pp. e0187621, 2017. Abstract
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Kato, S., S. Nakamori, S. Roujol, F. N. Delling, S. Akhtari, J. Jang, T. Basha, S. Berg, K. V. Kissinger, B. Goddu, et al., "Relationship between native papillary muscle T 1 time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathy", Journal of Cardiovascular Magnetic Resonance, vol. 18, no. 1: BioMed Central, pp. 79, 2017. Abstract
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2016
Jang, J., S. Bellm, S. Roujol, T. A. Basha, M. Nezafat, S. Kato, S. Weingärtner, and R. Nezafat, "Comparison of spoiled gradient echo and steady-state free-precession imaging for native myocardial T1 mapping using the slice-interleaved T1 mapping (STONE) sequence", NMR in Biomedicine, vol. 29, no. 10, pp. 1486–1496, 2016. Abstract
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Jang, J., S. Bellm, S. Roujol, T. A. Basha, M. Nezafat, S. Kato, S. Weingärtner, and R. Nezafat, "Comparison of spoiled gradient echo and steady‐state free‐precession imaging for native myocardial T1 mapping using the slice‐interleaved T1 mapping (STONE) sequence", NMR in Biomedicine, vol. 29, issue 10, pp. 1486-1496, 2016. Abstract
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Kato, S., S. Bellm, S. Roujol, J. Jang, T. Basha, S. Berg, K. V. Kissinger, B. Goddu, M. Maron, and W. J. Manning, "Diffuse Myocardial Fibrosis detected by Multi-slice T 1 Mapping using Slice Interleaved T 1 (STONE) Sequence in Patients with Hypertrophic Cardiomyopathy", Journal of Cardiovascular Magnetic Resonance, vol. 18, issue 1: BioMed Central, pp. 1, 2016. Abstract
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Kato, S., S. Bellm, S. Roujol, J. Jang, T. Basha, S. Berg, K. V. Kissinger, B. Goddu, M. Maron, W. J. Manning, et al., "Diffuse Myocardial Fibrosis detected by Multi-slice T1 Mapping using Slice Interleaved T1 (STONE) Sequence in Patients with Hypertrophic Cardiomyopathy", Journal of Cardiovascular Magnetic Resonance, vol. 18, no. 422: BioMed Central Ltd., 2016. Abstract
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Basha, T. A., S. Bellm, S. Roujol, S. Kato, and R. Nezafat, "Free-breathing slice-interleaved myocardial T2 mapping with slice-selective T2 magnetization preparation", Magnetic resonance in medicine, vol. 76, no. 2, pp. 555–565, 2016. Abstract
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Akcakaya, M., T. Basha, C. Tsao, S. Berg, K. V. Kissinger, B. Goddu, W. J. Manning, and R. Nezafat, "High-resolution late gadolinium enhancement imaging with compressed sensing: a single-center clinical study", Journal of Cardiovascular Magnetic Resonance, vol. 18, issue 1: BioMed Central, pp. 1, 2016. Abstract
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Akcakaya, M., T. Basha, C. Tsao, S. Berg, K. V. Kissinger, B. Goddu, W. J. Manning, and R. Nezafat, "High-resolution late gadolinium enhancement imaging with compressed sensing: a single-center clinical study", Journal of Cardiovascular Magnetic Resonance, vol. 18, no. 1: BioMed Central, pp. O56, 2016. Abstract
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Akçakaya, M., S. Weingärtner, T. A. Basha, S. Roujol, S. Bellm, and R. Nezafat, "Joint myocardial T1 and T2 mapping using a combination of saturation recovery and T2-preparation", Magnetic resonance in medicine, vol. 76, no. 3, pp. 888–896, 2016. Abstract
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Tang, M., T. Basha, S. Berg, K. V. Kissinger, B. Goddu, W. J. Manning, and R. Nezafat, "Left atrial wall imaging using a novel black-blood late gadolinium enhancement sequence", Journal of Cardiovascular Magnetic Resonance, vol. 18, issue 1: BioMed Central, pp. 1, 2016. Abstract
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Tang, M., T. Basha, S. Berg, K. V. Kissinger, B. Goddu, W. J. Manning, and R. Nezafat, "Left atrial wall imaging using a novel black-blood late gadolinium enhancement sequence", Journal of Cardiovascular Magnetic Resonance, vol. 18, no. S1: BioMed Central, pp. P62, 2016. Abstract
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