@article {Yehia2011620,
	title = {Pulsatile systems for colon targeting of budesonide: In vitro and in vivo evaluation},
	journal = {Drug Delivery},
	volume = {18},
	number = {8},
	year = {2011},
	note = {<p>cited By 4</p>
},
	pages = {620-630},
	abstract = {<p>The purpose of this study is to increase the lag time and prevent release of budesonide, a corticosteroid drug used in Crohn{\textquoteright}s disease for the first 5h and efficiently deliver it to the colon. Eudragit S100 spray-coated capsules and pulsatile systems using tablet plugs of cellulose acetate butyrate (CAB), HPMC K4M, guar gum, and pectin were prepared. Eudragit S100-coated capsules released 80.62\% after 5h. In pulsatile systems, decreasing the ratio of the polymer significantly increased the rate and extent of drug release. Spray-coating with EUD S100 decreased the extent of drug release to 48.41\%, 69.94\%, 80.58\%, and 45.23\% in CAB, HPMC K4M, pectin, and guar gum, respectively; however, the entire amount was released in the target area. In the presence of bacterial enzymes, selected formulas showed nearly 100\% release. X-ray imaging performed to monitor the capsules throughout the GIT in human volunteers of the capsules and spray-coated pulsatile systems with 25\% guar gum in the plug showed bursting in the transverse and ascending colon, respectively. Both formulations showed marked reduction in induced rabbit colitis model. {\textcopyright} 2011 Informa Healthcare USA, Inc.</p>
},
	doi = {10.3109/10717544.2011.621987},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-82055161857\&partnerID=40\&md5=cd8c233c4fbc37af8f9cf7320897ecad},
	author = {Yehia, S.A. and A.H. Elshafeey and I. Elsayed}
}
