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Nagieb, C. S., T. A. - E. H. Harhash, H. L. Fayed, and S. Ali, "Evaluation of diode laser versus topical corticosteroid in management of Behcet's disease-associated oral ulcers: a randomized clinical trial.", Clinical oral investigations, 2021. Abstract

OBJECTIVES: The current trial was conducted to assess the effect of diode laser therapy compared to topical corticosteroid in management of oral ulcers of BD.

MATERIALS AND METHODS: Fifty patients were divided randomly into two parallel groups. The first group received 980 nm diode laser; the second group received topical corticosteroid (0.1% triamcinolone acetonide). The outcome measures included oral ulcer activity index (composite index), pain (VAS), number of oral ulcers, healing time, and oral health-related quality of life (OHIP-14). The collected data were analyzed for any statistical significance.

RESULTS: A statistically significant difference was detected between laser and corticosteroid groups favoring laser on comparing composite index and VAS scores on the first and third days and on comparing number of ulcers on the third and fifth days. A statistically significant difference was detected between laser and corticosteroid groups on comparing scores of the questions assessing discomfort with eating food, irritability with other people, taste worsening, unsatisfactory diet, and painful aching on the first and/or third days. No adverse effects were reported by participants of both groups.

CONCLUSIONS: Diode laser is efficient safe treatment modality for management of BD-associated oral ulcers. Diode laser was more efficient than triamcinolone acetonide in controlling pain and reducing oral ulcer activity.

CLINICAL RELEVANCE: Laser therapy is efficient safe modality that could spare BD patient from adding a new medication to their long list, being just one visit compared to other regular daily regimen medications.

TRIAL REGISTRATION: registration number: NCT03771768.

MIKHAIL, C. H. R. I. S. T. I. N. E., K. H. A. L. E. D. ELGAALY, A. Abd El Latif Abd El Hamid, O. Shaker, and S. Ali, "Gustatory Dysfunction among a Sample of Depressed Egyptian Adults under Antidepressants Therapy: A Retrospective Cohort Study.", International journal of dentistry, vol. 2021, pp. 5543840, 2021. Abstract

It is quite clear that the ability to perceive taste sensations significantly affects food choice, which consequently affects health status in the long term. Gustatory dysfunction is a neglected symptom among the depressed patients and those under antidepressants therapy, although these patients are suspectable to oral problems, due to general self-negligence related to mental disease, fear of dental treatment, and side effects of varied medications utilized in psychiatry. This study is aimed at assessing gustatory thresholds (detection and recognition thresholds) among a sample of 30 depressed Egyptian adults under antidepressants therapy for at least 3 months or psychotherapy with age ranging from 20 to 50 years old, seeking the Psychiatric Clinic at the Faculty of Medicine, Cairo University, Egypt. These patients were distributed into three equal groups (tricyclic antidepressants (TCA), selective serotonin reuptake inhibitors (SSRIs), and psychotherapy) and were assessed for gustatory detection and recognition thresholds using the filter paper disc method through a scoring system. The participants were also divided into normal taste group in which both the detection and recognition scores were 1, while the scores from 2 till 5 were considered as hypogeusia group and the score of 6 was considered as dysgeusia group. The TCA group was statistically significant from the other 2 groups in sweet detection thresholds ( = 0.043) and sweet recognition thresholds ( = 0.007). Hypogeusia for sweet was statistically significant ( = 0.041), where it was more common among TCA (70%) than both SSRIs and the psychotherapy group (20%). Gustatory dysfunction was found to be mostly associated with TCA followed by SSRIs particularly for sweet taste thresholds. More attention has to be given to taste changes among these patients as oral health affects general health by causing considerable pain and by changing what people eat, their speech, and their quality of life and wellbeing. Proper awareness and evaluation of this problem will improve the quality of life for the depressed patients and avoid unnecessary treatment. This trial is registered with ID: NCT03599011.

Ali, S., "Review of the current evidence of non-HLA gene polymorphism in oral lichen planus", Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, vol. 33, issue 3, pp. 334-339, 2021.
Magdy, E., and S. Ali, "Stratification of methotrexate-induced oral ulcers in rheumatoid arthritis patients", Special care in dentistry , vol. 41, issue 3, pp. 367-371, 2021.
Moussa, A. - A. M. A., F. Zahran, W. A. Moneim, and S. Ali, "Awareness of systemic diseases effect on oral health among Egyptian dentists: A briefing report.", Special care in dentistry , vol. 40, issue 5, pp. 531-532, 2020.
Abdelkawy, M., S. Ali, A. N. Fahmi, and O. Shaker, "The Efficacy of Squamous Cell Carcinoma Antigen in the Differential Diagnosis of Oral squamous Cell Carcinoma", Egyptian Dental Journal, vol. 66, issue 3, pp. 1611-1617, 2020.
, "Evaluation of Salivary versus Serum Squamous Cell Carcinoma Antigen in Oral lichen Planus", Egyptian Dental Journal, vol. 66, issue 3, pp. 1519-1525, 2020.
Ali, S., M. Abdelkawy, S. Ali, and L. Rashed, "miR-21 and TAC as Salivary Biomarkers for Oral Dysplasia", Advanced Dental Journal, vol. 2, issue 4, pp. 209-217, 2020.
Abd el-Aziz, A., A. AbouShousha, S. Ali, and F. Zahran, "Prevalence of Potentially Malignant Lesions and Oral Cancer Among Smokers in an Egyptian cohort: A Hospital-based Cross-Sectional Study", Advanced Dental Journal, vol. 2, issue 3, pp. 93-100, 2020.
Ali, S., "Light Based Detection Systems in Oral Cancer Detection: Merit or Demerit", MSA 1st international Dental Conference, 21 February, 2019.
Ali, S., M. Abdelkawy, and S. Ali, "miR-21 and TAC as Salivary Biomarkers for Oral Dysplasia", CED-IADR/NOF Oral Health Research Congress, Madrid, Spain, 19 September, 2019.
Ali, S., M. Abelkawy, and W. Wahbi, "Do nutraceuticals and herbal medicines have a role in managing oral lichen planus? A systematic review", 14th Biennial Congress of the European Association of Oral Medicine in conjunction with the World Workshop on Oral Medicine VII, Gothenburg, Sweden, 28 September, 2018.
Belal, M., W. A. Elmoneim, B. Mostafa, and S. Ali, "VELscope versus toluidine blue for detection of dysplastic changes in oral keratotic lesions: diagnostic accuracy study", jasmr, vol. 13, issue 1, pp. 45-52, 2018.
Abdelradi, F., F. Adbelgawad, S. Ali, and M. Z. Ewiss, "THE APPLICABILITY OF INNOSPICE MODEL IN DEVELOPING COUNTRIES: A CASE STUDY", International Conference on Education and New Learning Technologies, Spain, March, 2017.
S., A., and W. W., "The efficacy of aloe vera in management of oral lichen planus: a systematic review and meta-analysis", Oral Diseases, vol. 23, issue 7, pp. 913-918, 2017.
S., A., "Evaluation of bcl-2 expression in cigarette smokers", EDJ, vol. 63, pp. 417-424, 2017.
S., A., and A. E., "Evaluation of the salivary level of miR-21 in cigarette smokers: Case-control study", EDJ, vol. 63, pp. 401-406, 2017.
Rashed, L., R. A. N. I. A. ABDEL HAY, M. Alkaffas, and S. Ali, "Studying the association between methylene tetrahdrofolate reductase (MTHFR) 677 gene polymorphism, cardiovascular risk and lichen planus", Journal of oral pathology and medicine, vol. 46, issue 10, pp. 1023-1029, 2017.
S., H., E. A. S., and F. H., "Evaluation of Apoptosis versus Proliferation in Various Clinical Forms of Oral Lichen Planus.", EDJ, vol. 60, issue 3, pp. 3115-3123, 2014.