El-Hawary, S. S., M. A. Rabeh, M. El-Raey, E. A. M. El-Kadde, and U. R. Abdelmohsen, "Metabolomic profiling of three Araucaria species, and their possible potential role against COVID-19; ", Journal of Biomolecular Structure and Dynamics, 2021.
El-Hawary, S. S., M. A. Taher, Ellham Amin, and S. F. AbouZid, "Genus Tabebuia: A comprehensive review journey from past achievements to future perspectives", Arabian Journal of Chemistry , vol. 14, issue 4: 103046, 2021.
El-Hawary, S. S., R. A. El-Fitiany, O. M. Mousa, A. A. A. Salama, and R. E. A. Gedaily, "Metabolic profiling and in vivo Hepatoprotective activity of Malpighia glabra L. leaves;", Journal of Food Biochemistry, vol. 45:e13588, 2021. jfbc.13588.pdf
Sayed, A. E. M., S. M. Ezzat, E. M. M. Nagar, and S. E. S. Hawary, "In vivo diabetic wound healing effect and HPLC–DAD–ESI–MS/MS profiling of the methanol extracts of eight Aloe species.", Revista Brasileira de Farmacognosia, vol. 26, pp. 352-362, 2016. in_vivo_diabetic_wound_healing_effect_and_hplcdadmsms_profiling.pdf
Hawary, S. E. S., R. Mohammed;, S. F. AbouZid, Z. Y. Ali, A. O. El-Gendy, and Ahlam Elwekeel, "In-vitro Cyclooxygenase Inhibitory, Antioxidant and Antimicrobial Activities of Phytochemicals Isolated from Crassula Arborescens (Milt) Willd;", International Journal of Applied Research in Natural Products, vol. 9, issue 4, pp. 8-14, 2016.
ElHawary, S. S., S. Saad, A. M. El Halawany, Z. Y. Ali, and M. El Bishbishy, "Phenolic content and anti-hyperglycemic activity of pecan cultivars from Egypt.", Pharmaceutical biology, vol. 54, issue 5, pp. 788-98, 2016. Abstractphenolic_content_and_anti_hyperglycemic_activity_of_pecan_cultivars_from_egypt.pdf

CONTEXT: Pecans are commonly used nuts with important health benefits such as anti-hyperglycemic and anti-hyperlipidemic effects.

OBJECTIVE: A comparative investigation of the antihyperglycemic and total phenolic content of the leaves and shells of four pecan cultivars growing in Egypt was carried out. The selected cultivars (cv.) were Carya illinoinensis Wangneh. K. Koch. cv. Wichita, cv. WesternSchely, cv. Cherokee, and cv. Sioux family Juglandaceae.

MATERIALS AND METHODS: Total phenolic and flavonoid contents of the leaves and shells of pecan cultivars were carried out using Folin-Ciocalteu's and aluminum chloride assays, respectively. Moreover, HPLC profiling of phenolic and flavonoid contents was carried out using RP-HPLC-UV. In addition, in vivo anti-hyperglycemic activity of the ethanolic extracts (125 mg/kg bw, p.o.) of C. illinoinensis cultivars was carried out using streptozotocin (STZ)-induced diabetes in Sprague-Dawley rats for 4 weeks.

RESULTS AND DISCUSSION: Phenolic contents were higher in shells than leaves in all studied cultivars, while flavonoids were higher in leaves. Leaves and shells of cv. Sioux showed the highest phenolics (251.7 µg gallic acid equivalent (GAE)/g), and flavonoid contents (103.27 µg rutin equivalent (RE)/g and 210.67 µg quercetin equivalent (QE)/g), respectively. The HPLC profiling of C. illinoinensis cultivars resulted in the identification of eight flavonoids (five of these compounds are identified for the first time from pecan), and 15 phenolic acids (six are identified for the first time from pecan). Leaves of cv. Sioux revealed the most potent decrease in blood glucose and glycated hemoglobin (HbA1c%) (194.9 mg/dl and 6.52%, respectively), among other tested cultivars. Moreover, leaves of cv. Sioux significantly elevated serum total antioxidant capacity (TAC) and reduced glutathione (GSH) (0.33 mMol/l and 30.68 mg/dl, respectively), and significantly suppressed the markers of both lipid peroxidation (malondialdehyde, MDA) and protein oxidation (protein carbonyl, PC) (14.25 µmol/ml and 3.18 nmol/mg protein, respectively).

CONCLUSION: Different pecan cultivars showed significant variation in its phenolic and flavonoid contents and consequently their antioxidant and anti-hyperglycemic effects.

El-Hawary, S. S., R. Mohammed, S. AbouZid, Z. Y. Ali, and Ahlam Elwekeel, "Anti-arthritic activity of 11-O-(4'-O-methyl galloyl)-bergenin and Crassula capitella extract in rats.", Journal of pharmacy and pharmacology, vol. 68, issue 6, pp. 834-44, 2016 Jun. Abstract

OBJECTIVES: Isolation and identification of phytochemicals of Crassula capitella (Thunberg), evaluation of the anti-arthritic potential of the extract and the major isolated compound; 11-O-(4'-O-methyl galloyl)-bergenin and underlying their mechanism on rat model of rheumatoid arthritis (RA).

METHODS: Different fractions were subjected to column chromatography giving fourteen compound identified by mass and NMR spectroscopic techniques. RA was induced by intraplantar injection of complete Freund's adjuvant into the right hind paw of rats. Influence of tested samples in comparable to methotrexate on paw oedema, body weight gain, serum diagnostic markers, cartilage and bone degeneration enzymes, pro-inflammatory mediators and oxidative stress biomarkers in arthritic rats.

KEY FINDINGS: Fourteen phenolic compounds were isolated and identified for the first time from C. capitella. The major compound identified as 11-O-(4'-O-methyl galloyl)-bergenin. Treatment of arthritic rats with extract or 11-O-(4'-O-methyl galloyl)-bergenin with the tested doses can reduce the progression and severity of RA.

CONCLUSION: Crassula capitella is a new natural and abundant source for 11-O-(4'-O-methyl galloyl)-bergenin for resolving chronic inflammatory diseases as RA through antioxidant, anti-inflammatory and membrane stabilizing mechanism.

Salah, N. M., A. H. M. E. D. M. A. SOULEMAN, K. H. Shaker, S. E. Hawary, Z. A. El-Shahid, and F. A. K. El-Hady, "Acetylcholinesterase, Alpha-Glucosidase and Tyrosinase Inhibitors from Egyptian Propolis", International Journal of Pharmacognosy and Phytochemical Research, vol. 9, issue 4, pp. 528-536, 2017. acetylcholinesterase_alpha-glucosidase_and_tyrosinase_inhibitors.pdf
Hawary, S. E., A. ElSayed, M. W. Helmy, E. M. B. El Naggar, H. S. Marzouk, and S. M. Bassam, "DNA fingerprinting, biological and chemical investigation of certain Yucca species", Natural Product Research, vol. 32, issue 21, pp. 2617-2620, 2018.