The utilization of 2-aminoprop-1-ene-1,1,3-tricarbonitrile as a precursor to quinoline, furan and thiophene derivatives with antitumor activities
- Citation:
- Mohareb, R. M., D. H. Fleita, and O. K. Sakka, "The utilization of 2-aminoprop-1-ene-1,1,3-tricarbonitrile as a precursor to quinoline, furan and thiophene derivatives with antitumor activities", Heterocyclic communications, 2011.
Abstract:
The condensation reaction of 2-aminoprop-1-ene-1,1,3-tricarbonitrile ( 1 ) with 2-acetyl-furan ( 2 ) afforded 2-amino-4-(furan-2-yl)penta-1,3-diene-1,1,3-tricarbonitrile ( 3 ). The latter compound underwent a series of heterocyclization reactions to give quinoline, furan, pyrazole and thiophene derivatives. The antitumor evaluation of the newly synthe-sized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Three of the synthesized compounds, namely 4 , 5d and 12 showed high inhibitory effects.
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