Utility of Ion-Associate Formation Reactions for the Spectrophotometric Determination of Sildenafil Citrate in Pure Form and in Virecta Tablets

Citation:
Frag, E. Y. Z., G. G. Mohamed, and H. M. S. Alelaiwi, "Utility of Ion-Associate Formation Reactions for the Spectrophotometric Determination of Sildenafil Citrate in Pure Form and in Virecta Tablets", PharmaceuticaAnalyticaActa, 2011.

Abstract:

A simple, rapid and sensitive extractive spectrophotometric method has been developed for the assay ofsildenafil citrate (SILC) in pure and pharmaceutical formulations (Virecta tablets). This method is based on theformation of chloroform soluble ion-pair of SILC with bromothymol blue (BTB) and methylene chloride soluble ionpairof SILC with bromophenol blue (BPB) and eriochrome blue black R (EBBR) in borax buffer of pH 3 and volume1mL for BTB while acetate buffer of pH 3 and volume 1mL for BPB and universal buffer of pH 2 and volume 1.5 mLfor EBBR with absorption maximum at 415, 420 nm and 510 nm for BTB, BPB and EBBR reagents, respectively.

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