Thermodynamics of the Reactions of [Pd (Et4en)(H2O)2]2+with Ligands of Biological Significance: Deactivation of Based-Drug By the Sulfur-Containing Biomolecules
- Citation:
- Shoukry, M. M., A. A. Al-Najjar, W. M. Hosny, A. E. Mahgoub, A. K. Abdelhadi, and P. A. Khalf-Alaa, "Thermodynamics of the Reactions of [Pd (Et4en)(H2O)2]2+with Ligands of Biological Significance: Deactivation of Based-Drug By the Sulfur-Containing Biomolecules", Journal of Sulpher Chem., vol. 32, pp. 563-573, 2011.
Abstract:
The reaction of [Pd(Et4en)(H2O)2]2+ (Et4en = N,N,N_,N_-tetraethylethylenediamine) with amino acids, peptides, dicarboxylic acids or DNA constituents was investigated at 37?C and 0.16M ionic strength. The stoichiometry and stability of the complexes formed were determined and the binding centers of the ligands were assigned. The concentration distribution diagrams of the complexes were evaluated. The equilibrium constants for the displacement of representative coordinated ligands such as inosine, glycine or methionine by mercaptoethylamine were calculated and the concentration distribution diagrams of the various species were evaluated.
Notes:
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