Synthesis of Some New Azole, Pyrimidine, Pyran, and Benzo/Naphtho[b]furan Derivatives Incorporating Thiazolo[3,2-a]benzimidazole Moiety
- Citation:
- Farag, A. M., K. M. Dawood, H. A. Abdel-Aziz, N. A. Hamdy, and I. M. I. Fakhr, "Synthesis of Some New Azole, Pyrimidine, Pyran, and Benzo/Naphtho[b]furan Derivatives Incorporating Thiazolo[3,2-a]benzimidazole Moiety", J. of Heterocyclic Chemistry, 2011.
Abstract:
Reaction of E-3-(N,N-dimethylamino)-1-(3-methylthiazolo[3,2-a]benzimidazol-2-yl)prop-2-en-1-one (1) with some N-nucleophiles, such as anilines 2a-c, 4-amino-N-pyridin-2-yl-benzenesulfonamide (4a), 4-amino-N-pyrimidin-2-yl-benzenesulfonamide (4b), hydrazine, hydroxylamine, thiourea, and guanidine afforded the corresponding arylaminoprop-2-en-1-one derivatives 3a-c, 5a,b, the pyrazole, isoxazole, pyrimidinethione and aminopyrimidine derivatives 7a, 7b, 9a, and 9b, respectively. The utility of compound 1, as a versatile building block, for the synthesis of the pyranone 13, benzo[b]furan 17a, and naphtho[1,2-b]furan 17b was also explored via its reaction with 2-benzamidoacetic acid (10), 1,4-benzoquinone (14a), and 1,4-naphthoquinone (14b), respectively.
Notes:
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