Basic Science Sector

Citation:

Farghaly, T. A., I. M. Abass, M. M. Abdalla, and R. O. A. Mahgoub, "Synthesis and Pharmacological Activities of Fused Pyrimidinones", World journal of chemistry, 2011.

Abstract:

A series of substituted 6-pyrazol-3-yl-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-ones 8 were prepared via reaction of 5-pyrazol-3-yl-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 3 or its methylthio derivatives 4 with hydrazonoyl chlorides 5. Both conventional thermal and microwave irradiation techniques were used for synthesis of the target products 8. A comparative study of these techinques in presence of a basic catalyst was performed. The mechanism of the studied reactions was discussed. Also, the products 8 were screend for their biological activities.

Notes:

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