Synthesis and Pharmacological Activities of Fused Pyrimidinones

Farghaly, T. A., I. M. Abass, M. M. Abdalla, and R. O. A. Mahgoub, "Synthesis and Pharmacological Activities of Fused Pyrimidinones", World journal of chemistry, 2011.


A series of substituted 6-pyrazol-3-yl-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-ones 8 were prepared via reaction of 5-pyrazol-3-yl-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 3 or its methylthio derivatives 4 with hydrazonoyl chlorides 5. Both conventional thermal and microwave irradiation techniques were used for synthesis of the target products 8. A comparative study of these techinques in presence of a basic catalyst was performed. The mechanism of the studied reactions was discussed. Also, the products 8 were screend for their biological activities.