Synthesis and Biological Activity Evaluation of Some NewHeterocyclic Spirocompounds with Imidazolinone and Pyrazoline Moieties

Citation:
Hassaneen, H. M., O. A. Miqdad, N. M. Abunada, and A. A. S. M. Samaha, "Synthesis and Biological Activity Evaluation of Some NewHeterocyclic Spirocompounds with Imidazolinone and Pyrazoline Moieties", International Journal of Chemistry, 2011.

Abstract:

The synthesis of antimicrobial activity spirocompounds was achieved via the reaction of hydrazonoyl halides 1 with exocyclic 4-arylidene-2-methylimidazolin-5-one 3 in benzene in the presence of triethylamine. Correct elemental analyses and spectral data (IR, 1H NMR, 13C NMR and MS) confirm the structure of the synthesized spirocompounds. All the synthesized compounds were evaluated in vitro for their antimicrobial activity against five gram-positive and two gram-negative bacteria using well diffusion method in Mueller-Hinton agar. Most of them exhibited significant antibacterial activity compared with selected standard drugs.

Notes:

n/a

Tourism