Basic Science Sector

Citation:

Rateb, N. M., S. H. Abdelaziz, and H. F. Zohdi, "Synthesis and Antimicrobial Evaluation of some New Thienopyridine, Pyrazolopyridine and Pyridothienopyrimidine Derivatives", Journal of Sulfur Chemistry, 2011.

Abstract:

Thieno[2,3-b]pyridines 7, 8, 9 were obtained via the S-alkylation of 3 with a variety of alkylating agents followed by cyclization in basic medium. On the other hand, compound 3 reacted with methyl iodide to give compound 10 which is converted to pyrazolo[3,4-b]pyridine derivative 13 by reaction with hydrazine hydrate. Pyrido[3`,2`:4,5]-thieno[3,2-d]pyrimidines derivatives 14, 16 were obtained by reaction of 7 with each of formic acid and formic/formamide, respectively. Alternatively, compound 14 was obtained by the reaction of 8 with formamide. Structures of the newly synthesized products were determined by elemental analysis and spectral data.

Notes:

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