Spectroscopic and biological activity studies on tridentate Schiff base ligandsand their transition metal complexes

El?Halima, H. F. A., M. M. Omar, G. G. Mohamed, and M. A. E.?E. Sayed, "Spectroscopic and biological activity studies on tridentate Schiff base ligandsand their transition metal complexes", European Journal of Chemistry 2 (2): 178?188 (2011), 2011.


Schiff base ligands are prepared via condensation of pyridine?2,6?dicarboxaldehyde with 2?aminothiophenol (H2L1) and 2?aminobenzoic acid (H2L2), respectively. The ligands arecharacterized based on elemental analysis, mass, IR and 1H NMR spectra. Metal complexes arereported and characterized based on elemental analyses, IR, 1H NMR, solid reflectance,magnetic moment, molar conductance, and thermal analyses (TG, DTG and DTA). The molarconductance reveals that all the metal chelates are non?electrolytes except Th(IV) H2L2complex which is 1:1 electrolyte . IR spectra show that H2L1 and H2L2 ligands behave asneutral tridentate ligands and bind to the metal ions via the two azomethine N and pyridine N. From the magnetic and solid reflectance spectra, it is found that the geometrical structures ofthese complexes are octahedral (Cr(III)? and Fe(III)?H2L1 and H2L2, Th(IV)?H2L2 and Mn(II)?H2L1 complexes) and triagonal bipyramidal (Co(II), Ni(II), Cu(II), Cd(II) and UO2(II)?H2L1 andH2L2 and Mn(II)?H2L2 complexes). The thermal behaviour of these chelates is studied using TGand DTA techniques and the activation thermodynamic parameters are calculated usingCoats?Redfern method. The synthesized ligands and their metal complexes were screened fortheir biological activity against bacterial species (Escherichia coli, P. vulgavis, B. subtilis and S.pyogones) and fungi (F. solani, A. niger and A. liavus). The activity data show that the metalcomplexes have antibacterial and antifungal activity more than the parent Schiff base ligandsagainst one or more bacterial or fungi species.