A Simple and Efficient Synthesis of New Substituted BenzothienopyridazineSpiro- Derivatives of Pyrazolone, Pyrimidinone and Diazepinone

Citation:
Faty, R. A. A. M., "A Simple and Efficient Synthesis of New Substituted BenzothienopyridazineSpiro- Derivatives of Pyrazolone, Pyrimidinone and Diazepinone", Chemical and Pharmaceutical Research., 2011.

Abstract:

Ethyl2-amino-4,5,6,7-tetrahydrobenzo [b] thiophene-3 carboxylate 1 was used as a starting material to synthesize 2a-c via coupling with acetyl acetone, ethylcyanoacetate or malononitrile,respectively.Heating under reflux in sodium ethoxide solution 2a-c gave 3a-c. When compounds 3a-c were heated under reflux in ethanol with hydrazine hydrate, thiourea or 1,2-diaminoethane and a catalytic amount of piperidine to produce the spiro compounds 4a-c, 5a-c and 6,respectively.

Notes:

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