Sensitive extractive spectrophotometric method for the determination of some statin drugs in pharmaceutical preparations

Citation:
Frag, E. Y. Z., G. G. Mohamed, and M. H. Gaber, "Sensitive extractive spectrophotometric method for the determination of some statin drugs in pharmaceutical preparations", Insight Pharmaceutical Sciences, vol. 1, issue 4, 2011.

Abstract:

Background: The statins (or HMG-CoA reductase inhibitors) formed a class of hypolipidemic drugs used to lower cholesterol levels in people with or at risk of cardiovascular disease. They lower cholesterol by inhibiting the enzyme HMG-CoA reductase, which is the rate-limiting enzyme of the mevalonate pathway of chloestrol synethesis. The context and purpose: Simple, sensitive and rapid extractive spectrophotometric method has been developed for the assay of statin drugs, simvastatin, pravastatin sodium and atorvastatin calcium, in pure form and in tablets. The method involves the formation of coloured ion-pairs between the drugs and the Mo(V)-thiocyanate

Notes:

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