Protective Effects of Potato Peel Powdered (Solanum Tuberosum, L) on The Management of Hypercholesterolemia In Albino Rats

Afify, A. E. - M. M. R., R. R.M., A. M. Hegazy, M. M. H. Osfor, and A. S. M. Elbahnasawy, "Protective Effects of Potato Peel Powdered (Solanum Tuberosum, L) on The Management of Hypercholesterolemia In Albino Rats", Int. J. of Academic Research, 2011.


Both dietary fibers and polyphenols have been reported to exert antihypercholesterolmia. Potato peel a waste by product of potato processing is found to be a good source of both dietary fiber and polyphenols. Polyphenols may provide beneficial effects on cardiovascular and hypercholesterolemia. The current study examined the attenuating influence of dietary potato peel powder on hypercholesterolemia and various oxidative stress-associated with biochemical parameters in hypercholesterolemic rats. Thirty two male albino rats weighing 110 + 10 g were divided in to four groups, the first group received the basal diet only and served as (negative control), the second group received the basal diet supplemented with 2% cholesterol +20% animal fat and 0.2% bile salt (hypercholesterolemic diet) and served as positive control), the other groups received hypercholesterolemic diet supplemented with 10%, 20% potato peel powder (Popp) for six weeks. The obtained results revealed that groups supplemented with 10% and 20% Popp significantly decrease total lipids, total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), liver enzymes: alanine aminotransferase (ALT), aspartate aminotransferase (AST) compared with positive control compared to positive and negative groups. Kidney functions also significantly decrease in urea and creatinine. Organs weight, body weight gain, HDL-C and blood picture parameters significantly increased compared with positive control. Moreover Popp can use to reduce the weight on hypercholesterolemic state and reducing hypercholesterolemic complications. In addition, PoPP also serves to improve the lipid profile (cholesterol, total lipid, triglycerides, LDL-C and HDL-C) and blood picture and to reduce the blood glucose level in hypercholesterolemic rats and could use in obese people for body loss.