Basic Science Sector

Citation:

Al-Othman, A. M., K. S. Al-Numair, G. E. El-Desoky, K. Yusuf, Z. A. A. Othman, M. A. M. Aboul-Soud, and J. P. Giesy, "Protection of ?-Tocopherol and Selenium Against Acute Effects of Malathion on Liver and Kidney of Rats", African Journal of Pharmacy and Pharmacology, 2011.

Abstract:

Protection from effects of the organophosphate insecticide, malathion on the liver and kidney of maleWistar albino rats by ?-tocopherol and selenium was investigated. Significantly greater (P<0.01) meanconcentrations of malondialdehyde (MDA) and lesser concentrations (P<0.01) of reduced glutathione(GSH) and tissues total proteins were observed in liver and kidney of rats exposed to malathion.Activities of the antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathioneperoxidase (GPx) were less in livers and kidneys of rats exposed to malathion. These effects caused byexposure to malathion were reversed when rats were subsequently treated orally with 100 mg/kg b.w.tocopherol and/or 0.1 mg selenium/kg b.w. Both tocopherol and selenium (Se) reduced theconcentration of MDA, and increased concentration of total proteins and reduced glutathione and meanactivities of SOD, CAT and GPx, to levels that were not significantly different from unexposed, controlrats, previous to exposure to malathion.

Notes:

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