Basic Science Sector

Citation:

El-Jakee, J., K. F. Mohamed, and S. A. Marouf, "Preparation of Autogenous Bivalent Vaccine for M", Life Science Journal, 2011.

Abstract:

In view of the decreasing effectiveness of antibiotics in controlling Mycoplasma infections and no vaccine is available against Mycoplasma in Egypt, the need for reliable vaccines has become even more urgent. The present study tried to prepare two bivalent autogenous vaccines (saponised and formalized vaccines) able to protect against M. bovis and M. bovigenitalium. The prepared vaccines were experimentally injected in groups of rabbits and challenged with virulent strain of M. bovis and M. bovigenitalium. Both saponised and formalized vaccines were able to protect rabbit against M. bovis and M. bovigenitalium. Meanwhile saponised vaccine was safe and more potent than formalized vaccine. Experimental work had shown that a vaccine inactivated with saponin can protect in the face of a large Mycoplasma challenge and was highly immunogenic.

Notes:

n/a