Basic Science Sector

Citation:

El-Banna, H. A., and H. El-Zorba, "Pharmacokinetic of Florfenicol (Water Soluble Formulation) in Healthy and Pasteurella Infected Broiler Chickens", Journal of American Science, 2011.

Abstract:

Florfenicol has been approved in the European Union for use in cattle and pigs as an injectable solution for treatment of respiratory diseases in cattle through injection .But now, it was introduced in some countries as an oral solution for the treatment of several poultry diseases. The aim of the present study is to describe the Pharmacokinetics of florfenicol (water soluble formulation)in broiler chickens after either a single intravenous and oral administration (by a dose of 30 mg/kg-1 body weight). Meanwhile, comparing its disposition in control healthy and Pasteurella-infected broilers. Following the IV administration of the drug in healthy and diseased birds, the drug plasma concentration declined in a biphasic pattern. The maximum plasma concentration of florfenicol in control healthy and diseased was reached one hour after its oral administration. But the peak level detected in control broilers was higher than that detected in infected birds. Conclusion: Data of the present study showed that volume of distribution, total body clearance in infected birds were higher than that determined in healthy ones. On the other hands, systemic bioavailability were significantly lower (F %,55.6 %) in diseased broiler compared to values determined in healthy ones (F % ,71.5).

Notes:

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