In the present work RAPD-PCR was used to study the relatedness among 10 strains of both Candida albicans and Cryptococcus neoformans previously isolated from man, animals and soil in El-Fayoum Governorate. The profile of DNA fragments for C. albicans strains showed the differentiation of the genomic DNA of C. albicanss isolates into numbers of DNA bands, which were different in molecular weight. The dendogram analysis of RAPD pattern of C. albicans isolates using specific primers divided the isolates into 3 groups of high similarity (92 - 100 %) and a group of low similarity (21%).
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