The Effect of Lead Acetate Toxicity on Experimental Male Albino Rat

Ibrahim, N. M., E. A. Eweis, H. S. El-Beltagi, and Y. E. Abdel-Mobdy, "The Effect of Lead Acetate Toxicity on Experimental Male Albino Rat", Biological Trace Element Research, vol. 144, pp. 1120-1132, 2011.


The toxic effect of Pb ion (lead acetate) was investigated using male albino rats, which was ingested at 1/20, 1/40, and 1/60 sublethal doses. Relative to normal control, the ingestion of Pb2+ induced significant stimulation in ALT and AST activity. In addition, total soluble protein and albumin contents of plasma were decreased, while the content of globulin was changed by the Pb2+ treatments. The cholinesterase activity was inhibited, but the activities of alkaline and acid phosphates as well as lactate dehydrogenase were stimulated as a result of lead acetate intoxication. These observations were gradually paralleled across the experiment dose of the three doses of intoxicated Pb2+. In the case of blood picture, Pb2+ ingestion significantly reduced the contents of hemoglobin and RBC count of intoxicated rat’s blood, while the plasma levels of T3 and T4 and blood WBC count were insignificantly decreased or unchanged. All results of the present study showed that the Pb2+ ingestion was more effective in the case of the high dose (1/20 LD50) than that of the low dose (1/60 LD50) ingestion relative to the normal healthy control. The results of the present work advice the need to avoid exposure of humans to the lead compound to avoid injurious hazard risk.