Effect of Aspartame on some Oxidative Stressparameters in Liver and Kidney of Rats
- Citation:
- Mourad, I. M., "Effect of Aspartame on some Oxidative Stressparameters in Liver and Kidney of Rats", African Journal of Pharmacy and Pharmacology, vol. 5, issue 6, pp. 678-682, 2011.
Abstract:
Aspartame is one of the most widely used artificial sweeteners in over 90 countries worldwide. It is ahighly intensity sweetener added to a large variety of food, most commonly found in low caloriebeverages, desserts and table top sweeteners added to tea or coffee. The present study examinedwhether the daily oral administration of ASP (40 mg/kg) for 2, 4 and 6 weeks induce oxidative stress inthe liver and kidney of male albino rats. Lipid peroxidation (LPO), glutathione reduced (GSH) levels aswell as the activities of superoxide dismutase (SOD), glutathione-S-transferase (GST) and catalase (CAT) enzymes were determined. A significant increase in LPO levels was obtained in the liver tissueafter 4 and 6 weeks of ASP administration while there was a significant decrease in LPO level after 2weeks followed by a significant increase in the renal tissue at the end of the 6 weeks. SOD activitysignificantly decreased in the liver tissue after 2, 4 and 6 weeks of treatment. Also, there was asignificant decrease in SOD activity after 2 and 4 weeks in the renal tissue. CAT activity significantly decreased in the liver tissue after 2 and 4 weeks of ASP administration. Regarding to GSH content, there was a significant decrease in the liver tissue after 2, 4 and 6 weeks which was accompanied by asignificant increase in GST activity after 4 and 6 weeks of ASP administration. In conclusion, ASP may induce an oxidative stress in the liver and kidney of male albino rats.
Notes:
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