Basic Science Sector

Citation:

Ghany, W. A..A. E. -, "Comparison between ImmunoglobulinsIgy and the Vaccine for Prevention of Infectious Bursal Disease in Chickens", Global Veterineria, 2011.

Abstract:

This study was designed to compare between the efficacy of immunoglobulineIgY and the vaccine in the prevention of broiler chickens against infectious bursal disease virus (IBVD) infection. In this study 18-week old white Leghorn laying chickens were received live intermediate strain IBVD vaccine (D78) followed by a booster doses of inactivated oil adjuvanted IBVD vaccine. The eggs of the hens were used for the separation of yolk polyclonal IgY. Enzyme Linked Immuno Sorbent Assay (ELISA) was used to determine the titer of antibodies in the serum and yolk. To evaluate the efficacy of the vaccine and IgY preparation against IBVD infection, day-old Hubbard broiler chicks were divided equally into 5 groups. The first group was received live intermediate IBVD vaccine (D78), the second group was given IgY preparation, the third group received both the vaccine and IgY, the fourth group was kept as control challenged. Chickens in the first, second, third and fourth group were challenged by the virulent field IBVD strain. Chickens of the fifth group were kept as blank control (not vaccinated, not IgY treated and not challenged). Morbidity and mortality rates and post mortem lesions, the bursa/body weight (B/BW) ratios and the histopathological examination of the bursae were investigated as criteria for evaluation. In conclusion, the vaccine and IgY were relatively equally effective but their combination was is superior in prevention of IBVD infection in broiler chickens.

Notes:

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