The Chemopreventive Effect of Ginkgo Biloba and Silybum Marianum Extracts on Hepatocarcinogenesis In Rats
- Citation:
- Mesallamy, H. E. O., N. S. Metwally, M. S. Soliman, K. A. Ahmed, and M. A. M. Moaty, "The Chemopreventive Effect of Ginkgo Biloba and Silybum Marianum Extracts on Hepatocarcinogenesis In Rats", Cancer Cell International, pp. 11-38, 2011.
Abstract:
This study was designed to evaluate the potential chemopreventive activities of Ginkg biloba extract (EGb) and Silybum marianum extract (silymarin) against hepatocarcinogenesis induced by N-nitrosodiethylamine (ND EA) in rats. Rats were divided into 6 groups. Group 1 served as normal control rats. Group 2 animals were intragastrically administrated N DEA a t a dose of 10 mg/k g five times a week for 12 weeks to induce hepatocellular carcinoma (HCC). Groups 3 and 4 animals were pretreated with silymarin and E Gb respectively. Groups 5 and 6 animals were post treated with silymarin and EGb respectively. The investigated parameters in serum alanine aminotransferase (ALT), aspartate a minotrasferase (AST), gamma glutamyltransferase (GGT) and vascular endothelial growth factor (VEGF). The investigated parameters in liver tissue are malondialdehyde (MDA), glutathione (GS H ), superoxide dismutase ( SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and comet assay parameters.
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