Biochemical Changes in Experimental Diabetes Before and Aftertreatment with Mangifera Indica and Psidium Guava Extracts
- Citation:
- Rawi, S. M., I. M. Mourad, and D. A.Sayed, "Biochemical Changes in Experimental Diabetes Before and Aftertreatment with Mangifera Indica and Psidium Guava Extracts", Int J Pharm Biomed Sci., vol. 2, pp. 29-41, 2011.
Abstract:
Male adult albino rats were used to study the hypoglycemic effect of Mangiferaindica and Psidium guajava aqueous extracts either used individually or incombination of as well as the effect of glibenclamide as reference sulfonylureasdrug at the dose level of 0.5 mg/kg body weight in streptozotocin-diabetic rats.Preliminary test using different doses of each plant indicated that the most effectivedoses were 250 mg/kg body weight for each plant. Our studies was extended toinclude the effect of the tested doses on different biochemical parameters includingserum insulin concentration, hepatic glycogen content, total proteins, total lipidsand transaminases activities in serum and liver. The obtained data of the abovementioned investigations revealed great alleviation of the impaired glucose tolerance, serum insulin and hepatic glycogen content, also serum and hepatic totalprotein contents were increased as a result of treatment. In STZ-diabetic rats, theactivities of (ALT, AST and ALP) either detected in sera or hepatic tissues wereincreased, then the activities were improved as a result of treatments.
Notes:
n/a