Anti-Alzheimer Activity of Novel 1,3,4-Thiadiazole Derivatives

Abdallah, M. A., T. A. Farghaly, and M. A. M. A. andZienab Muhammad, "Anti-Alzheimer Activity of Novel 1,3,4-Thiadiazole Derivatives", World journal of chemistry, vol. 6, issue 2, pp. 96-106, 2011.


The reaction of the new enaminone 2 with ?-ketohydrazonoyl chlorides 3 afforded 5-(pyrazol-4-yl)-carbonyl-2-benzoylimino-1,3,4-thiadiazoles 5. Treatment of 5a with hydrazine hydrate led to formation of pyrazolo[3,4-d]pyridazine derivatives 8. The reaction of enaminone 2 with 6-amino-2-thioxopyrimidin-4-one 9 in acetic acid under reflux produced 2-thioxopyridopyrimidinone derivative 10. The latter compound or its methylthio derivative 15 reacts with hydrazonoyl chlorides 3 to give pyridotriazolopyrimidine derivatives 14. The newly synthesized compounds 2, 5, 8 and 14 were tested for their anti-alzheimer activity, and the results which obtained revealed their potency as drugs for Alzheimer disease.



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