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Darwish, E. S., M. A. Mosselhi, F. M. Altalbawy, and H. A. Saad, "Synthesis, Acidity Constants and Tautomeric Structure of the Diazonium Coupling Products of 2-(Benzylsulfanyl)-7H-purin-6-one in Its Ground and Excited States", Molecules, 2011. Abstract

A series of new 8-arylhydrazono-2-(benzylsulfanyl)-7H-purin-6-ones 6 were synthesized, their electronic absorption spectra in different organic solvents of varying polarities were investigated and their acid dissociation constants in both the ground and excited states were determined spectrophotometrically. The tautomeric structures of such products were elucidated by spectral analyses and correlation of their acid dissociation constants with the Hammett equation. The results indicated that the studied compounds 6 exist predominantly in the hydrazone tautomeric form 6A in both the ground and excited states.

Mohamed, M. A., E. K. A. Abdelall, Y. H. Zaki, and A. O. Abdelhamid, "Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2?a]benzimidazole derivatives containing pyridine moiety", European Journal of Chemistry, 2011. Abstract

Pyrazolo[1,5?a]pyrimidine, [1,2,4]triazolo[1,5?a]-pyrimidine and pyrimido[1,2?a] benzimida?zole derivatives were synthesized by reaction of sodium salt of 3?hydroxy?(1?pyridin?2? yl)prop?2?en?1?one or sodium salt of 3?hydroxy?1?(pyridin?3?yl)prop?2?en?1?one with different heterocyclic amines in piperidenium acetate. Also,

Farag, A. M., K. M. Dawood, H. A. Abdel-Aziz, N. A. Hamdy, and I. M. I. Fakhr, "Synthesis of Some New Azole, Pyrimidine, Pyran, and Benzo/Naphtho[b]furan Derivatives Incorporating Thiazolo[3,2-a]benzimidazole Moiety", J. of Heterocyclic Chemistry, 2011. Abstract

Reaction of E-3-(N,N-dimethylamino)-1-(3-methylthiazolo[3,2-a]benzimidazol-2-yl)prop-2-en-1-one (1) with some N-nucleophiles, such as anilines 2a-c, 4-amino-N-pyridin-2-yl-benzenesulfonamide (4a), 4-amino-N-pyrimidin-2-yl-benzenesulfonamide (4b), hydrazine, hydroxylamine, thiourea, and guanidine afforded the corresponding arylaminoprop-2-en-1-one derivatives 3a-c, 5a,b, the pyrazole, isoxazole, pyrimidinethione and aminopyrimidine derivatives 7a, 7b, 9a, and 9b, respectively. The utility of compound 1, as a versatile building block, for the synthesis of the pyranone 13, benzo[b]furan 17a, and naphtho[1,2-b]furan 17b was also explored via its reaction with 2-benzamidoacetic acid (10), 1,4-benzoquinone (14a), and 1,4-naphthoquinone (14b), respectively.

Amin, R. S., K. M. El-Khatib, A. R. M. Hameed, E. R. Souaya, and M. A. Etman, "Synthesis of Pt", Applied Catalysis A, 2011. Abstract
Ali, K. A., E. A. Ragab, and T. F. M. A. M. Abdalla, "Synthesis of new functionalized 3-substituted [1,2,4]triazolo [4,3-a]pyrimidine derivatives: potential antihypertensive agents", Acta Pol Pharm, 2011. Abstract

A convenient synthesis of a series of thiosemicarbazide, 1,3,4-oxadiazole, 1,3,4-thiadiazole, thiazole, 1,2,4-triazole, pyrazole and dioxoisoindoline derivatives incorporating 1,2,4-triazolo[4,3-a]pyrimidine via the reaction of the readily accessible 1,5-dihydro-5-oxo-1.7-diphenyl-1,2.4-triazolo[4,3-a]pyrimidine-3-carbohydrazide (2) with the appropriate reagents is described. The newly synthesized compounds were found to possess antihypertensive and diuretic activities compared to captopril and furosemide as reference controls, respectively.

Mohareb, R. M., G. A. Elmegeed, O. M. E. Abdel-Salam, S. H. Doss, and M. G. William, "Synthesis of Modified Steroids as A Novel Class of Non-Ulcerogenic, Anti-Inflammatory and Anti-Nociceptive Agents", Steroids, 2011. Abstract

The identification of compounds able to treat both pain and inflammation with limited side effects is one of the prominent goals in biomedical research. This study aimed at the synthesis

Mohamed, M. S., A. A. Shoukry, and A. G. Ali, "Synthesis and Structural Characterization of Ternary Cu (II) Complexes of Glycine with 2,2- Bipyridineand 2,2-Dipyridylaminethe DNA-Binding Studies and Biological Activity", SpectrochimicaActa Part A: Molecular and Biomolecular Spectroscopy, 2012.
Elfeky, S. A., and A. - S. A. Al-Sherbini, "Synthesis and Spectral Characteristics of Gold Nanoparticles Labelled with Fluorescein Sodium", Current Nanoscience, vol. 7, issue 6, pp. 1028-1033., 2011. AbstractCU-PDF.pdf

The biological application of labeled nanoparticles is a rapidly developing area of nanotechnology that raises new possibilities in the diagnosis and treatment of human cancers. Gold nanoparticles (GNPs) have been prepared via wet chemical method. Fluorescein capped gold nanoparticles have been prepared by a reduction of the HAuCl4 in boiling fluorescein sodium solution. The results indicated that the spectrum exhibits one curve with two absorption bands at

A.-Hafaz, S. E. - D. H., M. I. A.-Monem, M. G. Mohamed, Mettwally, and F. M. Abdelrazek, "Synthesis and reactions of some new Selenopheno[2,3-c]pyridazines", Chem. Heterocyclic Compounds, 2011. Abstract
Hamid, A. Z., A. M. T. El-khair, and H. B. Hassan, "Synthesis and Protection of AM50 Magnesium Alloy and its Composites using Environmentally Pretreatment Electrolyte", Surface and Coatings Technology, vol. 206, issue 6, pp. 1041–1050, 2011. Abstract

This article details with the synthesis and surface modification of AM50 magnesium alloy and its composite (AM50-5%ZrO2 and AM50-10% ZrO2) substrate to improve the corrosion resistance. Environmentally friendly chemical conversion coating based on permanganate–phosphate solution was used in this study. Deposition of electroless Ni–P alloy and electrodeposition Ni onto AM50 magnesium alloys have been carried out. The influences of pretreatment steps on the surface morphology and composition analysis have been studied using scanning electron microscope/energy dispersed X-ray system (SEM/EDS). Additionally, the surface morphology and phase composition of the coatings were determined with (SEM/EDS) and X-ray diffraction (XRD), respectively. Moreover, potentiodynamic polarization tests have been used to estimate the corrosion behavior of unprotected and protected AM50 Mg and its composite alloys in 5% NaCl solutions.

Farghaly, T. A., I. M. Abass, M. M. Abdalla, and R. O. A. Mahgoub, "Synthesis and Pharmacological Activities of Fused Pyrimidinones", World journal of chemistry, 2011. Abstract

A series of substituted 6-pyrazol-3-yl-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-ones 8 were prepared via reaction of 5-pyrazol-3-yl-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 3 or its methylthio derivatives 4 with hydrazonoyl chlorides 5. Both conventional thermal and microwave irradiation techniques were used for synthesis of the target products 8. A comparative study of these techinques in presence of a basic catalyst was performed. The mechanism of the studied reactions was discussed. Also, the products 8 were screend for their biological activities.

A.El-Sherif, A., "Synthesis and Characterization of some Potential Antitumorpalladium(II) Complexes of 2-aminomethylbenzimidazoleand amino Acids", Coordination Chemistry, 2011. Abstract

The stoichiometry and stability constants of the complexes formed between [Pd (AMBI)(H2O)2]2+, (AMBI = 2-(aminomethyl)-benzimidazole) with some selected bio-relevant ligands containing different functional groups, were investigated at 25 0C and 0.1 M ionic strength. The ligands used are imidazole, cysteine, glutathione (GSH), threonine, aspartic acid, 1,1-cyclobutane dicarboxylic acid (CBDCA) and lysine. The stoichiometry and stability constants of the formed complexes are also reported, and the concentration distribution of the various complex species was evaluated as a function of pH. The results show ring opening of CBDCA and monodentate

Mohamed, G. G., H. A. F. El-halim, M. M. I. El-Dessouky, and W. H. Mahmoud, "Synthesis and Characterization of Mixed Ligand Complexes of Lome?oxacin Drug and Glycine with Transition Metals", J. Molecular structure, 2011.
Hassaneen, H. M., O. A. Miqdad, N. M. Abunada, and A. A. S. M. Samaha, "Synthesis and Biological Activity Evaluation of Some NewHeterocyclic Spirocompounds with Imidazolinone and Pyrazoline Moieties", International Journal of Chemistry, 2011. Abstract

The synthesis of antimicrobial activity spirocompounds was achieved via the reaction of hydrazonoyl halides 1 with exocyclic 4-arylidene-2-methylimidazolin-5-one 3 in benzene in the presence of triethylamine. Correct elemental analyses and spectral data (IR, 1H NMR, 13C NMR and MS) confirm the structure of the synthesized spirocompounds. All the synthesized compounds were evaluated in vitro for their antimicrobial activity against five gram-positive and two gram-negative bacteria using well diffusion method in Mueller-Hinton agar. Most of them exhibited significant antibacterial activity compared with selected standard drugs.

Rateb, N. M., S. H. Abdelaziz, and H. F. Zohdi, "Synthesis and Antimicrobial Evaluation of some New Thienopyridine, Pyrazolopyridine and Pyridothienopyrimidine Derivatives", Journal of Sulfur Chemistry, 2011. Abstract

Thieno[2,3-b]pyridines 7, 8, 9 were obtained via the S-alkylation of 3 with a variety of alkylating agents followed by cyclization in basic medium. On the other hand, compound 3 reacted with methyl iodide to give compound 10 which is converted to pyrazolo[3,4-b]pyridine derivative 13 by reaction with hydrazine hydrate. Pyrido[3`,2`:4,5]-thieno[3,2-d]pyrimidines derivatives 14, 16 were obtained by reaction of 7 with each of formic acid and formic/formamide, respectively. Alternatively, compound 14 was obtained by the reaction of 8 with formamide. Structures of the newly synthesized products were determined by elemental analysis and spectral data.

Mabkhot, Y. N., N. A. Kheder, and A. M. Farag, "Synthesis and Antimicrobial Evaluation of Some New Tetrahydropyrimidine Derivatives", Heterocycles, 2011. Abstract

The utility of 1,2,3,4-tetrahydropyrimidine-5-carboxylate (1a,b), and 1,2-dihydropyrimidine-5-carboxylate (2) in the synthesis of some new functionalized pyrimidine derivatives such as 6-(2-(dimethylamino)vinyl)-1,2,3,4-tetrahydropyrimidine,6-(1-cyano -2-(phenylamino)-2-thioxoethyl)-1,2,3,4-tetrahydropyrimidine and 4,6-distyryl-1,2-dihydropyrimidine derivatives is reported. Antimicrobial evaluation of some selected examples from the synthesized products was carried out and showed promising results.

Ali, K. A., H. M. Hosni, E. A. Ragab, and S. A. I. and El-Moez, "Synthesis and Antimicrobial Evaluation of Some New Cyclooctanones and Cyclooctane-Based Heterocycles", Arch. Pharm. Chem. Life Sci., 2011. Abstract
Altalbawy, F. M. A., and E. S. S. Darwish, "Synthesis and Antimicrobial Activity of 1,2,4-Triazolo[4,3-b][1,2,4,5]tetrazines", Asian Journal of Chemistry, 2011. Abstract

Synthesis of 4-phenylamino-5-phenyl-4H-[1,2,4]triazole-3-thiol (1) and 3-methylthio-4-phenylamino-5-phenyl-4H-[1,2,4]triazole (2) is described. Reactions of hydrazonoyl halides (3) with either 1 or 2 afforded 1,2,4-triazol[4,3-b][1,2,4,5]tetrazine. The latter products were screened for their antifungal and antibacterial properties. The structure of the products was established based on elemental and spectral analyses. Further evidence for the assigned structure of the products is based on alternative synthesis. The mechanism of the studied reactions was also discussed.

Kamel, G. M., E. N. A. eldeen, M. Y. El-Mishad, and R. F. Ezzat, "Susceptibility Pattern of Pseudomonas aeruginosa Against Antimicrobial Agents and Some Plant Extracts with Focus on its Prevalence in Different Sources", Global Veterinaria, 2011. Abstract

The present study was performed to isolate, characterize and evaluate the prevalence of Pseudomonas. aeruginosa in 340 samples of different sources (human, chicken, animals and environment), as well as detection of haemolysin production and determing its susceptibility to different antimicrobials.

Kamel, G. M., E. N. A. eldeen, M. Y. El-Mishad, and R. F. Ezzat, "Susceptibility Pattern of Pseudomonas aeruginosa Against Antimicrobial Agents and Some Plant Extracts with Focus on its Prevalence in Different Sources", Global Veterinaria, 2011. Abstract

The present study was performed to isolate, characterize and evaluate the prevalence of Pseudomonas. aeruginosa in 340 samples of different sources (human, chicken, animals and environment), as well as detection of haemolysin production and determing its susceptibility to different antimicrobials.