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Farghaly, T. A., I. M. Abass, M. M. Abdalla, and R. O. A. Mahgoub, "Synthesis and Pharmacological Activities of Fused Pyrimidinones", World journal of chemistry, 2011. Abstract

A series of substituted 6-pyrazol-3-yl-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-ones 8 were prepared via reaction of 5-pyrazol-3-yl-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 3 or its methylthio derivatives 4 with hydrazonoyl chlorides 5. Both conventional thermal and microwave irradiation techniques were used for synthesis of the target products 8. A comparative study of these techinques in presence of a basic catalyst was performed. The mechanism of the studied reactions was discussed. Also, the products 8 were screend for their biological activities.

A.-Hafaz, S. E. - D. H., M. I. A.-Monem, M. G. Mohamed, Mettwally, and F. M. Abdelrazek, "Synthesis and reactions of some new Selenopheno[2,3-c]pyridazines", Chem. Heterocyclic Compounds, 2011. Abstract
Mohareb, R. M., G. A. Elmegeed, O. M. E. Abdel-Salam, S. H. Doss, and M. G. William, "Synthesis of Modified Steroids as A Novel Class of Non-Ulcerogenic, Anti-Inflammatory and Anti-Nociceptive Agents", Steroids, 2011. Abstract

The identification of compounds able to treat both pain and inflammation with limited side effects is one of the prominent goals in biomedical research. This study aimed at the synthesis

Ali, K. A., E. A. Ragab, and T. F. M. A. M. Abdalla, "Synthesis of new functionalized 3-substituted [1,2,4]triazolo [4,3-a]pyrimidine derivatives: potential antihypertensive agents", Acta Pol Pharm, 2011. Abstract

A convenient synthesis of a series of thiosemicarbazide, 1,3,4-oxadiazole, 1,3,4-thiadiazole, thiazole, 1,2,4-triazole, pyrazole and dioxoisoindoline derivatives incorporating 1,2,4-triazolo[4,3-a]pyrimidine via the reaction of the readily accessible 1,5-dihydro-5-oxo-1.7-diphenyl-1,2.4-triazolo[4,3-a]pyrimidine-3-carbohydrazide (2) with the appropriate reagents is described. The newly synthesized compounds were found to possess antihypertensive and diuretic activities compared to captopril and furosemide as reference controls, respectively.

Amin, R. S., K. M. El-Khatib, A. R. M. Hameed, E. R. Souaya, and M. A. Etman, "Synthesis of Pt", Applied Catalysis A, 2011. Abstract
Farag, A. M., K. M. Dawood, H. A. Abdel-Aziz, N. A. Hamdy, and I. M. I. Fakhr, "Synthesis of Some New Azole, Pyrimidine, Pyran, and Benzo/Naphtho[b]furan Derivatives Incorporating Thiazolo[3,2-a]benzimidazole Moiety", J. of Heterocyclic Chemistry, 2011. Abstract

Reaction of E-3-(N,N-dimethylamino)-1-(3-methylthiazolo[3,2-a]benzimidazol-2-yl)prop-2-en-1-one (1) with some N-nucleophiles, such as anilines 2a-c, 4-amino-N-pyridin-2-yl-benzenesulfonamide (4a), 4-amino-N-pyrimidin-2-yl-benzenesulfonamide (4b), hydrazine, hydroxylamine, thiourea, and guanidine afforded the corresponding arylaminoprop-2-en-1-one derivatives 3a-c, 5a,b, the pyrazole, isoxazole, pyrimidinethione and aminopyrimidine derivatives 7a, 7b, 9a, and 9b, respectively. The utility of compound 1, as a versatile building block, for the synthesis of the pyranone 13, benzo[b]furan 17a, and naphtho[1,2-b]furan 17b was also explored via its reaction with 2-benzamidoacetic acid (10), 1,4-benzoquinone (14a), and 1,4-naphthoquinone (14b), respectively.

Mohamed, M. A., E. K. A. Abdelall, Y. H. Zaki, and A. O. Abdelhamid, "Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2?a]benzimidazole derivatives containing pyridine moiety", European Journal of Chemistry, 2011. Abstract

Pyrazolo[1,5?a]pyrimidine, [1,2,4]triazolo[1,5?a]-pyrimidine and pyrimido[1,2?a] benzimida?zole derivatives were synthesized by reaction of sodium salt of 3?hydroxy?(1?pyridin?2? yl)prop?2?en?1?one or sodium salt of 3?hydroxy?1?(pyridin?3?yl)prop?2?en?1?one with different heterocyclic amines in piperidenium acetate. Also,

Darwish, E. S., M. A. Mosselhi, F. M. Altalbawy, and H. A. Saad, "Synthesis, Acidity Constants and Tautomeric Structure of the Diazonium Coupling Products of 2-(Benzylsulfanyl)-7H-purin-6-one in Its Ground and Excited States", Molecules, 2011. Abstract

A series of new 8-arylhydrazono-2-(benzylsulfanyl)-7H-purin-6-ones 6 were synthesized, their electronic absorption spectra in different organic solvents of varying polarities were investigated and their acid dissociation constants in both the ground and excited states were determined spectrophotometrically. The tautomeric structures of such products were elucidated by spectral analyses and correlation of their acid dissociation constants with the Hammett equation. The results indicated that the studied compounds 6 exist predominantly in the hydrazone tautomeric form 6A in both the ground and excited states.

Dawood, K. M., H. A. Mohamed, H. Abdel-Gawad, and F. A. Badria, "Synthesis, anti-HSV-1, and cytotoxic activities of some Newpyrazole- and Isoxazole-Based Heterocycles", Med. Chem. Res., 2011.
Elsabee, M. Z., E. A. Ali, S. M. Mokhtar, and M. Eweis, "Synthesis, Characterization Polymerization and Antibacterial Properties of Novel Thiophene Substituted Acrylamide", Reactive and Functional Polymers, 2011. Abstract

Ethyl 2-acrylamido-4,5,6,7-tetrahydrobenzo [b] thiophene-3-carboxylate (ETTCA) has been synthesized and its structure has been elucidated by elemental analysis and spectral tools. Free radical polymerization of (ETTCA) has been conducted in several solvents using azobisisobutyronitrile (AIBN) as an initiator.

Hassaneen, H. M., H. M. E. Hassaneen, and Y. S. M. R. M. Pagni, "Synthesis, Reactions and Antibacterial Activity of 3-Acetyl[1,2,4]triazolo-[3,4-a]isoquinoline Derivatives using Chitosan as Heterogeneous Catalyst under Microwave Irradiation", Z. Naturforsch., 2011. Abstract

3-Acetyl[1,2,4]triazolo[3,4-a]isoquinolines were prepared using chitosan as a catalyst. These compounds were used to prepare a novel series of enaminones 5, and their reactions with hydrazonoyl halides 1 and 11 gave triazoloisoquinolines 8 and 13, respectively, with a carbonylpyrazole side chain. Hydrazinolysis of 8 and 13 gave the pyrazolopyridazines 10 and pyrazolopyridazinones 14. Reaction of 5 with hydroximoyl halides 15 led to triazoloisoquinoline 16 with a carbonylisoxazole side chain. Antibacterial effects of compounds 8 and 10 were studied.

El-Ansary, A. L., H. M. Abdel-Fatah, and N. S. Abdel-Kader, "Synthesis, Spectral, Thermal and Magnetic Studies of Mn(II), Ni(II) and Cu(II) Complexes with Some Benzopyran-4-one Schiff bases", Spectrochim. Acta A, 2011. Abstract

The Schiff bases of N2O2 dibasic ligands, H2La and H2Lb are prepared by the condensation of ethylenediamine (a) and trimethylenediamine (b) with 6-formyl-7-hydroxy-5-methoxy-2-methylbenzopyran-4-one. Also tetra basic ligands, H4La and H4Lb are prepared by the condensation of aliphatic amines (a) and (b) with 6-formyl-5,7-dihydroxy-2-methylbenzopyran-4-one. New complexes of H4La and H4Lb with metal ions Mn(II), Ni(II) and Cu(II) are synthesized, in addition Mn(II) complexes with ligands H2La and H2Lb are also synthesized. Elemental and thermal analyses, infrared, ultraviolet-visible as well as conductivity and magnetic susceptibility measurements are used to elucidate the structure of the newly prepared metal complexes. The structures of copper (II) complexes are also assigned based upon ESR spectra study. All the complexes separated with the stoichiometric ratio (1:1) (M:L) except Mn-H4La and Mn-H4Lb with (2:1) (M:L) molar ratio. In metal chelates of the type 1:1 (M:L), the Schiff bases behave as a dinegative N2O2 tetradentate ligands. Moreover in 2:1 (M:L) complexes, the Schiff base molecules act as mono negative bidentate ligand and binuclear complex is then formed. The Schiff bases were assayed by the disc diffusion method for antibacterial activity against Staphylococcus aureus and Escherichia coli. The antifungal activity of the Schiff bases was also evaluated against the fungi Aspergillus flavus and Candida albicans.

El-halim, H. A. F., M. M. Omar, and G. G. Mohamed, "Synthesis, Structural, Thermal Studies and Biological Activity of A Tridentate Schiff Base Ligand and their Transition Metal Complexes", Spectrochimica Acta, 2011. Abstract

Schiff base (L) ligand is prepared via condensation of pyridine-2,6-dicarboxaldehyde with 2-aminopyridine. The ligand and its metal complexes are characterized based on elemental analysis, mass, IR, solid re?ectance, magnetic moment, molar conductance, and thermal analyses (TG, DTG and DTA). The molar conductance reveals that all the metal

Zayed, M. A., G. G. Mohamed, and S. A. M. Abdullah, "Synthesis, Structure Investigation, Spectral Characteristics and Biologicalactivities of some Novel Azodyes", Spectrochimica Acta, 2011.
Metwally, N. H., and S. El-Taher, "Synthesis, Theoretical Study and Antimicrobial Activity of Novel Polysubstiuted Thiazoles", Heterocycles, 2011. Abstract

New 5-(9H-Fluoren-9-ylidene)- and 5-(1H-indan-1-ylidene)-2-thioxo-4-thiazolidinones 3a,b were synthesized Eco-friendly under microwave irradiation(MWI). These compounds undergo alkaline hydrolysis to afford thecorresponding thiol derivatives 4a,b, which cyclized into polysubstituted thiazoles 6a-h using arylazomalononitriles 5a-d as nucleophilic agents. Some selected products were tested for their antimicrobial activities. The equilibrium geometries of the studied compounds were calculated at the B3LYP/6-31G(d) level of the density functional theory (DFT). Conformational analysis has been carried out to determine the most stable conformers. The relative stability of the azo and hydrazo tautomers has been investigated. The HOMO-LUMO energy gap is used in rationalizing the reactivity of the studied compounds.

Abdel-Wahab, B. F., H. A. Mohamed, A. A. Farahat, and K. M. Dawood, "Synthetic Accesses to Azolylthiazoles", Heterocycles, 2011. Abstract

Published data over the last years on the methods of synthesis and biological applications of azolylthiazoles are reviewed here for the first time till 2011. The review was classified according to the type of azole ring linked to thiazole.

Afify, A. E. - M. M. R., S. A. Fayed, E. A. Shalaby, and H. A. and El-Shemy, "Syzygium Cumini (pomposia) Active Principles Exhibit Potent Anticancer and Antioxidant Activities", African Journal of Pharmacy and Pharmacology, 2011. Abstract

The antioxidant and anticancer activities of Syzygium cumini fruit extracts were investigated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical-scavenging assay and viability of leukemia cancer cells (AML cell line) respectively. The successive extracts, hexane, chloroform, ether, ethyl acetate, ethanol and water were prepared and subjected to antioxidant and anticancer evaluation. The results showed that the ethanol extract had stronger antioxidant and anti- leukemia activities than the other ones. Spectroscopic methods data of active ingredients separated from ethanol extract indicated that S.cumini fruit extracts contained phenolic compounds, such as Kaempferol 7-O-methylether and sterols such as ?-Sitosterol responsible for their antioxidant and anticancer activities.

Frag, E. Y. Z., G. G. Mohamed, and H. M. S. Alelaiwi, "Utility of Ion-Associate Formation Reactions for the Spectrophotometric Determination of Sildenafil Citrate in Pure Form and in Virecta Tablets", PharmaceuticaAnalyticaActa, 2011. Abstract

A simple, rapid and sensitive extractive spectrophotometric method has been developed for the assay ofsildenafil citrate (SILC) in pure and pharmaceutical formulations (Virecta tablets). This method is based on theformation of chloroform soluble ion-pair of SILC with bromothymol blue (BTB) and methylene chloride soluble ionpairof SILC with bromophenol blue (BPB) and eriochrome blue black R (EBBR) in borax buffer of pH 3 and volume1mL for BTB while acetate buffer of pH 3 and volume 1mL for BPB and universal buffer of pH 2 and volume 1.5 mLfor EBBR with absorption maximum at 415, 420 nm and 510 nm for BTB, BPB and EBBR reagents, respectively.

Hegazy, A. K., L. Boulos, and K. H. F. O. S. Sharashy, "Vegetation and Species Altitudinal Distribution in Al-Jabal Al-Akhdar Landscape, Libya", P Acad Nat Sci Phila, 2011. Abstract

Cyrenaica is the largest phytogeographical region in Libya. The region holds Al-Jabal Al-Akhdar (the Green Mountain)landscape with the richest vegetation and highest species diversity in the country. Field study of the vegetation was carriedout in the different habitat types representing the mountainous landscape. Data were analyzed by Detrended Correspondence analysis (DCA) and Canonical Correspondence Analysis (CCA) against the environmental variables. Vegetation and speciesrichness varied with altitude from the sea level, through mid elevation slope vegetation in wadis, to herbaceous and lowshrub-vegetation towards the mountain top. Vegetation is classified into three major groups: (1) coastal and low altitudevegetation dominated by shrubs and trees which constitute about 60% of the plant life forms; (2) mid altitude and wadivegetation with the highest species richness and dominated by shrubs and trees which constitute over 60% of the plant lifeforms; and (3) mountain top vegetation dominated by herbs and few low shrubs constituting up to 90% of the plant lifeforms. The altitude, aspect and soil parameters do not explain the majority of variance in the obtained data which reveal thatother diverse local conditions and habitat types seem to be the main determinant of vegetation variation in Al-Jabal Al-Akhdar landscape.

Shaker, R. M., K. U. Sadek, E. A. Hafez, and M. AbdElrady, "5-Aminouracil as A Building Block in Heterocyclic Synthesis: Part IV", Zeitschrift for Naturforschung, vol. 66, pp. 843-849, 2011. AbstractCU-PDF.pdf


Afify, A. E. - M. M. R., H. S. El-Beltagi, S. A. Fayed, and E. A. and Shalaby, "Acaricidal Activity of Different Extracts from Syzygium Cumini L. Skeels (Pomposia) Against Tetranychus Urticae Koch", Asian Pacific Journal of Tropical Biomedicine, pp. 359-364, 2011. CU-PDF