Mohammed, H. S., H. A. S. ezz, Y. A. Khadrawy, and N. A. Noor,
"Neurochemical and Electrophysiological Changes Induced by Paradoxical Sleep Deprivation in Rats",
Behavioural Brain Research, vol. 225, pp. 39-46, 2011.
AbstractConcentrations of amino acid neurotransmitters were assessed in the hippocampus and cortex using HPLC. Control data showed slight differences from normal animals in the delta, theta and alpha waves while an increase in the beta wave was obtained. After 24 h of PSD, delta relative power increased and the rest of EEG wave’s power decreased with respect to control. After 48 h and 72 h the spectral power analysis showed non-significant changes to control. The amino acid neurotransmitter analysis revealed a significant increase in cortical glutamate, glycine and taurine levels while in the hippocampus, glutamate, aspartate, glutamine and glycine levels increased significantly. Both the waking EEG and neurotransmitter analyses suggest that PSD induced neurochemical and electrophysiological changes that may affect brain proper functionality. © 2011 Elsevier B.V. All rights reserved.